Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Background: Fibroproliferative disorders result in excessive scar formation, are associated
with high morbidity, and cost billions of dollars every year. Of these, keloid disease presents …

Keloid are a fibroproliferative disorder caused by abnormal healing of skin, specifically
reticular dermis, when subjected to pathological or inflammatory scars demonstrating …

Pathological dermal scars such as keloids present significant clinical challenges lacking
effective treatment options. Given the distinctive feature of highly stiffened scar tissues …

Background Fibroblasts found in keloid tissues are known to present an altered sensitivity to
microenvironmental stimuli. However, the impact of changes in extracellular matrix stiffness …

Chronic senescence, such as aging, contributes to age-related tissue dysfunction and
disease development. The accumulation of senescent fibroblasts and the senescence …

Abnormal activation of fibroblasts plays a crucial role in keloid development. However, the
mechanism of fibroblast activation remains to be determined. YAP/TAZ are key molecules in …

Keloids are a severe form of scarring for which the underlying mechanisms are poorly
understood, and treatment options are limited or inconsistent. Although biomechanical …

Skin aging caused by various endogenous and exogenous factors results in structural and
functional changes to skin components. However, the role of senescent cells in skin aging …

Pathological scars (including keloids, hypertrophic scars, and scar contractures) are present
with high severity among certain populations, particularly in Asians and Africans who are …