Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Resident tissue macrophages (RTMs) encompass a highly diverse set of cells abundantly
present in every tissue and organ. RTMs are recognized as central players in innate immune …

Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors
determining disease progression are unclear. Transcriptional signatures associated with …

The remarkable ability of Mycobacterium tuberculosis to survive attacks from the host
immune response and drug treatment is due to the resilience of a few bacilli rather than a …

Summary Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active
tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the …

Globally, an estimated 107 million people have an alcohol use disorder (AUD) leading to 2.8
million premature deaths each year. Tuberculosis (TB) is one of the leading causes of death …

The tuberculosis (TB) vaccine Bacillus Calmette‐Guérin (BCG) was introduced 100 years
ago, but as it provides insufficient protection against TB disease, especially in adults, new …

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), continues to pose a
major public health problem and is the leading cause of mortality in people infected with …

Macrophages are a protective replicative niche for Mycobacterium tuberculosis (Mtb) but can
kill the infecting bacterium when appropriately activated. To identify mechanisms of …

Following Mycobacterium tuberculosis infection, alveolar macrophages are initially infected
but ineffectively restrict bacterial replication. The distribution of M. tuberculosis among …