A review of inflammatory mechanism in airway diseases
P Aghasafari, U George, R Pidaparti - Inflammation Research, 2019 - Springer
Background Inflammation in the lung is the body's natural response to injury. It acts to
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …
Mathematical models for immunology: current state of the art and future research directions
R Eftimie, JJ Gillard, DA Cantrell - Bulletin of mathematical biology, 2016 - Springer
The advances in genetics and biochemistry that have taken place over the last 10 years led
to significant advances in experimental and clinical immunology. In turn, this has led to the …
to significant advances in experimental and clinical immunology. In turn, this has led to the …
[PDF][PDF] A surprisingly poor correlation between in vitro and in vivo testing of biomaterials for bone regeneration: results of a multicentre analysis
ROC Oreffo, G Hulsart-Billström… - European Cells and …, 2016 - pearl.plymouth.ac.uk
New regenerative materials and approaches need to be assessed through reliable and
comparable methods for rapid translation to the clinic. There is a considerable need for …
comparable methods for rapid translation to the clinic. There is a considerable need for …
Translational systems biology of inflammation
Y Vodovotz, M Csete, J Bartels… - PLoS computational …, 2008 - journals.plos.org
Inflammation is a complex, multi-scale biologic response to stress that is also required for
repair and regeneration after injury. Despite the repository of detailed data about the cellular …
repair and regeneration after injury. Despite the repository of detailed data about the cellular …
Sepsis: Something old, something new, and a systems view
Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: current state and emerging prospects
Traumatic injury/hemorrhagic shock (T/HS) elicits an acute inflammatory response that may
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …
Insights into the role of chemokines, damage-associated molecular patterns, and lymphocyte-derived mediators from computational models of trauma-induced …
Significance: Traumatic injury elicits a complex, dynamic, multidimensional inflammatory
response that is intertwined with complications such as multiple organ dysfunction and …
response that is intertwined with complications such as multiple organ dysfunction and …
Mathematical models of the acute inflammatory response
Simulations using various methods can shed insight into the pathophysiology of the acute
inflammatory response and may lead to better design of clinical trials in sepsis and trauma. a …
inflammatory response and may lead to better design of clinical trials in sepsis and trauma. a …
Relevance of bioreactors and whole tissue cultures for the translation of new therapies to humans
The purpose of this review is to provide a brief overview of bioreactor‐based culture systems
as alternatives to conventional two‐and three‐dimensional counterparts. The role …
as alternatives to conventional two‐and three‐dimensional counterparts. The role …
A validated mathematical model of the cytokine release syndrome in severe COVID-19
RF Reis, AB Pigozzo, CRB Bonin… - Frontiers in molecular …, 2021 - frontiersin.org
By June 2021, a new contagious disease, the Coronavirus disease 2019 (COVID-19), has
infected more than 172 million people worldwide, causing more than 3.7 million deaths …
infected more than 172 million people worldwide, causing more than 3.7 million deaths …