Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

In the regulation of behavior, the role of GABA neurons has been extensively studied in the
circuit of fear, where GABA interneurons play key parts in the acquisition, storage and …

Basic and clinical studies demonstrate that stress and depression are associated with
atrophy and loss of neurons and glia, which contribute to the decreased size and function of …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Proper developmental, neural cell-type-specific, and activity-dependent regulation of
GABAergic transmission is essential for virtually all aspects of CNS function. The number of …

Synaptic plasticity confers environmental adaptability through modification of the
connectivity between neurons and neuronal circuits. This is achieved through changes to …

Epigenetic mechanisms, which control chromatin structure and function, mediate changes in
gene expression that occur in response to diverse stimuli. Recent research has established …

BACKGROUND: It is well known that exposure to severe stress increases the risk for
developing mood disorders. However, most chronic stress models in rodents involve at least …

Depression is associated with structural alterations in limbic brain regions that control
emotion and mood. Studies of chronic stress in animal models and postmortem tissue from …

Neuropsychiatric disorders place an enormous medical burden on patients across all social
and economic ranks. The current understanding of the molecular and cellular causes of …