Molecular profiling has transformed the diagnostic workflow of CNS tumors during the last
years. The latest WHO classification of CNS tumors (5th edition), published in 2021, pushed …

During the past decade, there has been an increased push toward the development of
precision cancer medicine, in hopes of tailoring treatments that effectively induce a …

Background Glioblastoma is the most common malignant primary brain tumour in adults and
driven by various genomic alterations. Next generation sequencing (NGS) provides timely …

Simple Summary In the search of the key factors that differentiate the aggressive
glioblastomas from lower-grade gliomas, we determined that the variants of the structural …

Gliomas are the most common malignant primary brain tumors characterized by poor
prognosis. The genotyping of tumors using next generation sequencing (NGS) platforms …

The standard treatment for glioblastoma involves a combination of surgery, radiation and
chemotherapy but have limited impact on survival. The exponential increase in targeted …

Genomic testing is a critical component of precision medicine. It has influenced many
aspects of patient care, including diagnosis, disease monitoring, and treatment choice …

Purpose. There has been a proliferation of commercially available tumor molecular profiling
services. However, there is a paucity of evidence as to whether these data result in treatment …