Mast cells originate from the CD34+/CD117+ hematopoietic progenitors in the bone marrow,
migrate into circulation, and ultimately mature and reside in peripheral tissues …

Many disordered proteins conserve essential functions in the face of extensive sequence
variation, making it challenging to identify the mechanisms responsible for functional …

Immunoglobulin E (IgE) plays a pivotal role in allergic responses,. The high-affinity IgE
receptor, FcεRI, found on mast cells and basophils, is central to the effector functions of IgE …

Mast cells are tissue-resident immune cells that function in both innate and adaptive
immunity through the release of both preformed granule-stored mediators, and newly …

The high-affinity immunoglobulin E (IgE) receptor, FcεRI, is the primary immune receptor
found on mast cells and basophils. Signal initiation is classically attributed to …

Perilla frutescens (L.) Britton is a classic herbal plant used widely against asthma in China.
But its mechanism of beneficial effect remains undermined. In the study, the antiallergic …

Background Perilla frutescens (L.) Britt., a classic medicinal plant, has been demonstrated to
have anti-inflammatory and anti-allergic effects in asthma. Perilla leaves extract (PLE) …

Abstract FcγRIIIa-FcεRIγ complexes, upon stimulation by antibodies, cluster to initiate
intracellular signaling and activate natural killer (NK) cells. Intracellular signaling involves …

Protein–protein binding domains are critical in signaling networks. Src homology 2 (SH2)
domains are binding domains that interact with sequences containing phosphorylated …

Tryptanthrin (TRYP) is the main active ingredient in Indigo Naturalis. Studies have shown
that TRYP had excellent anti-inflammatory activity, but its specific mechanism has been …