Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

Neurons completely transform how they regulate cell death over the course of their lifetimes.
Developing neurons freely activate cell death pathways to fine-tune the number of neurons …

ABSTRACT Retinal degeneration 10 (rd10) mice are a model of autosomal recessive
retinitis pigmentosa (RP), identified by Chang et al. in 2002 (Vision Res. 42: 517–525) …

OBJECTIVE: To investigate age-related changes of the retinal nerve fiber layer (RNFL)
imaged by a spectral-domain optical coherence tomography (OCT). DESIGN: Prospective …

purpose. To develop and characterize a retinal explant culture system to facilitate
investigation of novel methods of improving retinal stem cell therapy. methods. Retinas …

Apoptosis or programmed cell death is a critical regulator of tissue homeostasis and
emerging evidence is focused on the role of apoptosis mechanisms in the central nervous …

Aims or purpose Glaucoma is the leading cause of vision loss and blindness in the world.
Elucidating the pathogenesis of glaucoma and developing effective treatment should be the …

Ex vivo organ cultures represent unique research models, as they combine the advantages
of cell cultures with those of animal models. Being able to mimic in vivo situations through …

The intrinsic apoptotic pathway is essential for murine development. We have previously
shown that key mediators of this pathway, such as Bim, Apaf-1 and caspase-3, are down …

purpose. The purpose of this study was to examine the importance of calpains in retinal
ganglion cell (RGC) apoptosis and the protection afforded by calpain inhibitors against cell …