Extracellular adenosine concentrations are regulated by a panel of membrane transporters
which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two …

Nucleoside and nucleobase analogs are currently used in the treatment of solid tumors,
lymphoproliferative diseases, viral infections such as hepatitis and AIDS, and some …

Context Adrenocortical carcinoma (ACC) is rare and confers an unfavorable prognosis in
advanced stages. Other than combination chemotherapy with cisplatin, etoposide …

Pancreatic cancer is one of the most difficult malignancies to treat owing to the rapid
acquisition of resistance to chemotherapy. Gemcitabine, a first-line treatment for pancreatic …

The epithelial-mesenchymal transition (EMT) is a complex process in which cell phenotype
switches from the epithelial to mesenchymal one. The deregulations of this process have …

Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy,
characterized by ectopic calcification of spinal tissues. Symptoms include spine pain and …

Adenosine is a nucleoside that is particularly interesting to many scientific and clinical
communities as it has important physiological and pathophysiological roles in the kidney …

The epithelium-mesenchymal transition (EMT) is an important process of cell plasticity,
consisting in the loss of epithelial identity and the gain of mesenchymal characteristics …

Diabetic nephropathy ranks as the most devastating kidney disease worldwide. It
characterizes in the early onset by glomerular hypertrophy, hyperfiltration and mesangial …

Altered nucleoside levels may be linked to pathogenic signaling through adenosine
receptors. We hypothesized that adenosine dysregulation contributes to fibrosis in diabetic …