When tissue antigens and antibodies get along: revisiting the technical aspects of immunohistochemistry—the red, brown, and blue technique
JA Ramos-Vara, MA Miller - Veterinary pathology, 2014 - journals.sagepub.com
Once focused mainly on the characterization of neoplasms, immunohistochemistry (IHC)
today is used in the investigation of a broad range of disease processes with applications in …
today is used in the investigation of a broad range of disease processes with applications in …
Antibody validation
J Bordeaux, AW Welsh, S Agarwal, E Killiam… - …, 2010 - Taylor & Francis
Antibodies are among the most frequently used tools in basic science research and in
clinical assays, but there are no universally accepted guidelines or standardized methods …
clinical assays, but there are no universally accepted guidelines or standardized methods …
Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis
V Brune, E Tiacci, I Pfeil, C Döring, S Eckerle… - The Journal of …, 2008 - rupress.org
The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its
relationship to other lymphomas are largely unknown. This is partly because of the technical …
relationship to other lymphomas are largely unknown. This is partly because of the technical …
KIT pathway alterations in mucosal melanomas of the vulva and other sites
K Omholt, E Grafström, L Kanter-Lewensohn… - Clinical cancer …, 2011 - AACR
Purpose: A significant proportion of mucosal melanomas contain alterations in KIT. The aim
of this study was to characterize the pattern of KIT, NRAS, and BRAF mutations in mucosal …
of this study was to characterize the pattern of KIT, NRAS, and BRAF mutations in mucosal …
The PI3K/Akt pathway in tumors of endocrine tissues
HL Robbins, A Hague - Frontiers in endocrinology, 2016 - frontiersin.org
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis.
Defects in this pathway in human cancer syndromes such as Cowden's disease and Multiple …
Defects in this pathway in human cancer syndromes such as Cowden's disease and Multiple …
Spinal NMDA receptor phosphorylation correlates with the presence of neuropathic signs following peripheral nerve injury in the rat
C Ultenius, B Linderoth, BA Meyerson, J Wallin - Neuroscience letters, 2006 - Elsevier
Substantial evidence has established that activation of the NMDA receptor in the spinal
dorsal horn is essential for central sensitization—a phenomenon which comprises various …
dorsal horn is essential for central sensitization—a phenomenon which comprises various …
Chasing phosphohistidine, an elusive sibling in the phosphoamino acid family
JM Kee, TW Muir - ACS chemical biology, 2012 - ACS Publications
This year (2012) marks the 50th anniversary of the discovery of protein histidine
phosphorylation. Phosphorylation of histidine (pHis) is now widely recognized as being …
phosphorylation. Phosphorylation of histidine (pHis) is now widely recognized as being …
Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6
A Mottok, C Renné, K Willenbrock… - Blood, The Journal …, 2007 - ashpublications.org
Aberrant activities of JAK/STAT signaling pathways have been observed in several
hematologic malignancies. Here, we show high expression of JAK2 in the tumor cells of …
hematologic malignancies. Here, we show high expression of JAK2 in the tumor cells of …
Autocrine-and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma
C Renné, K Willenbrock, R Küppers, ML Hansmann… - Blood, 2005 - ashpublications.org
The pathogenesis of Hodgkin lymphoma (HL) is still largely unknown. Based on a search for
footprints of pathogenetic mechanisms in global RNA expression data of Hodgkin/Reed …
footprints of pathogenetic mechanisms in global RNA expression data of Hodgkin/Reed …
STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation
S Lassmann, I Schuster, A Walch, H Göbel… - Journal of clinical …, 2007 - jcp.bmj.com
Aims: To evaluate mRNA and protein expression of signal transducers and activators of
transcription (STAT) 3 in colorectal carcinomas (CRCs) and to define the association of …
transcription (STAT) 3 in colorectal carcinomas (CRCs) and to define the association of …