Simple Summary Prostate cancer (PCa) is a widespread malignancy, representing the
second leading cause of cancer-related death in men. In the last years, liquid biopsy has …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes,
but the spectrum of genome-wide alterations has not been profiled extensively in this …

Prostate cancer is the second most common cancer in men worldwide and causes over
250,000 deaths each year. Overtreatment of indolent disease also results in significant …

Abstract Characterization of the prostate cancer transcriptome and genome has identified
chromosomal rearrangements and copy number gains and losses, including ETS gene …

Annotation of prostate cancer genomes provides a foundation for discoveries that can
impact disease understanding and treatment. Concordant assessment of DNA copy number …

Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the
oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but …

It is unclear whether a single clone metastasizes and remains dominant over the course of
lethal prostate cancer. We describe the clonal architectural heterogeneity at different stages …

Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …

Purpose: The anaplastic large cell kinase gene (ALK) is rearranged in∼ 5% of lung
adenocarcinomas within the Asian population. We evaluated the incidence and the …