Air pollution, metabolites and respiratory health across the life-course

O Gruzieva, A Jeong, S He, Z Yu… - European …, 2022 - Eur Respiratory Soc
Previous studies have explored the relationships of air pollution and metabolic profiles with
lung function. However, the metabolites linking air pollution and lung function and the …

Update on metabolomic findings in COPD patients

J Gea, CJ Enríquez-Rodríguez… - ERJ Open …, 2023 - Eur Respiratory Soc
COPD is a heterogeneous disorder that shows diverse clinical presentations (phenotypes
and “treatable traits”) and biological mechanisms (endotypes). This heterogeneity implies …

J-edited DIffusional proton nuclear magnetic resonance spectroscopic measurement of glycoprotein and supramolecular phospholipid biomarkers of inflammation in …

P Nitschke, S Lodge, T Kimhofer, R Masuda… - Analytical …, 2022 - ACS Publications
Proton nuclear magnetic resonance (NMR) N-acetyl signals (Glyc) from glycoproteins and
supramolecular phospholipids composite peak (SPC) from phospholipid quaternary …

Diffusion and relaxation edited proton NMR spectroscopy of plasma reveals a high-fidelity supramolecular biomarker signature of SARS-CoV-2 infection

S Lodge, P Nitschke, T Kimhofer, J Wist… - Analytical …, 2021 - ACS Publications
We have applied nuclear magnetic resonance spectroscopy based plasma phenotyping to
reveal diagnostic molecular signatures of SARS-CoV-2 infection via combined diffusional …

Applying next-generation sequencing and multi-omics in chronic obstructive pulmonary disease

PY Tiew, OW Meldrum, SH Chotirmall - International journal of molecular …, 2023 - mdpi.com
Microbiomics have significantly advanced over the last decade, driven by the widespread
availability of next-generation sequencing (NGS) and multi-omic technologies. Integration of …

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the …

F Roth‐Walter, IM Adcock, C Benito‐Villalvilla… - Allergy, 2024 - Wiley Online Library
The accumulation of senescent cells drives inflammaging and increases morbidity of chronic
inflammatory lung diseases. Immune responses are built upon dynamic changes in cell …

Systematic review of NMR-based metabolomics practices in human disease research

K Huang, N Thomas, PR Gooley, CW Armstrong - Metabolites, 2022 - mdpi.com
Nuclear magnetic resonance (NMR) spectroscopy is one of the principal analytical
techniques for metabolomics. It has the advantages of minimal sample preparation and high …

Metabolome features of COPD: a scoping review

S Godbole, RP Bowler - Metabolites, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a complex heterogeneous disease state
with multiple phenotypic presentations that include chronic bronchitis and emphysema …

Metabolomics of asthma, COPD, and asthma-COPD overlap: an overview

S Dasgupta, N Ghosh, P Bhattacharyya… - Critical Reviews in …, 2023 - Taylor & Francis
The two common progressive lung diseases, asthma and chronic obstructive pulmonary
disease (COPD), are the leading causes of morbidity and mortality worldwide. Asthma …

Genetic association of inflammatory marker GlycA with lung function and respiratory diseases

Y Guo, Q Liu, Z Zheng, M Qing, T Yao, B Wang… - Nature …, 2024 - nature.com
Association of circulating glycoprotein acetyls (GlycA), a systemic inflammation biomarker,
with lung function and respiratory diseases remain to be investigated. We examined the …