[HTML][HTML] Sepsis—pathophysiology and therapeutic concepts

D Jarczak, S Kluge, A Nierhaus - Frontiers in medicine, 2021 - frontiersin.org
Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

Targeting cytokines, pathogen-associated molecular patterns, and damage-associated molecular patterns in sepsis via blood purification

K Moriyama, O Nishida - International journal of molecular sciences, 2021 - mdpi.com
Sepsis is characterized by a dysregulated immune response to infections that causes life-
threatening organ dysfunction and even death. When infections occur, bacterial cell wall …

Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19

JC Song, G Wang, W Zhang, Y Zhang, WQ Li… - Military Medical …, 2020 - Springer
Since December 2019, a novel type of coronavirus disease (COVID-19) in Wuhan led to an
outbreak throughout China and the rest of the world. To date, there have been more than …

Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury

R Wald, W Beaubien-Souligny, R Chanchlani… - Intensive care …, 2022 - Springer
Critical illness is often complicated by acute kidney injury (AKI). In patients with severe AKI,
renal replacement therapy (RRT) is deployed to address metabolic dysfunction and volume …

Renal replacement techniques in septic shock

T Hellman, P Uusalo, MJ Järvisalo - International Journal of Molecular …, 2021 - mdpi.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection; it carries a risk for mortality, considerably exceeding that of a mere …

[HTML][HTML] The effect of CytoSorb on inflammatory markers in critically ill patients: a systematic review and meta-analysis of randomized controlled trials

M Heymann, R Schorer, A Putzu - Critical Care Medicine, 2023 - journals.lww.com
OBJECTIVES: The effectiveness of CytoSorb at removing inflammatory mediators in critically
ill patients is controversial. DATA SOURCES: Electronic databases were searched from …

Mortality and adverse events of hemoadsorption with CytoSorb® in critically ill patients: A systematic review and meta‐analysis of randomized controlled trials

M Heymann, R Schorer, A Putzu - Acta Anaesthesiologica …, 2022 - Wiley Online Library
Background The effects and safety of extracorporeal hemoadsorption with CytoSorb® in
critically ill patients with inflammatory conditions are controversial. Methods We performed a …

The rationale and current status of endotoxin adsorption in the treatment of septic shock

J Śmiechowicz - Journal of clinical medicine, 2022 - mdpi.com
Lipopolysaccharide, the main component of the outer membrane of Gram-negative bacteria
is a highly potent endotoxin responsible for organ dysfunction in sepsis. It is present in the …

Immune modulation in sepsis, ARDS, and Covid-19—the road traveled and the road ahead

A Leligdowicz, MO Harhay, CS Calfee - NEJM evidence, 2022 - evidence.nejm.org
Immune Modulation in Sepsis, ARDS, and Covid-19 — The Road Traveled and the Road Ahead
| NEJM Evidence Skip to main content NEJM Evidence homepage Advanced Search SEARCH …

[HTML][HTML] Blood purification for adult patients with severe infection or sepsis/septic shock: a network meta-analysis of randomized controlled trials

JJ Chen, PC Lai, TH Lee, YT Huang - Critical Care Medicine, 2023 - journals.lww.com
OBJECTIVES: This study aimed to conduct a comprehensive and updated systematic review
with network meta-analysis (NMA) to assess the outcome benefits of various blood …