Depression is a well-known disabling mental illness characterized by sadness, loss of
interest in activities, and decreased energy. The symptoms of depression are usually …

The neuroimmune system plays a crucial role in the regulation of mood disorders. Moreover,
recent studies show that brain-derived neurotrophic factor (BDNF), a member of the …

Serotonergic psychedelics are emerging as potential antidepressant therapeutic tools, as
suggested in a recent randomized controlled trial with ayahuasca for treatment-resistant …

Anhedonia is defined as a diminished ability to experience interest or pleasure, and is a
critical psychopathological dimension of major depressive disorder (MDD). The purpose of …

Generalized anxiety disorder (GAD), the most frequently diagnosed form of anxiety, is
usually treated by cognitive-behavioural approaches or medication; in particular …

Depression has become one of the most commonly prevalent neuropsychiatric disorders,
and the main characteristics of depression are sleep disorders and melatonin secretion …

Background The chronic unpredictable mild stress (CUMS) model has long been
considered the best model for exploring the pathophysiological mechanisms underlying …

Pregnancy and lactation are reproductive processes that rely on physiological adaptations
that should be timely and adequately triggered to guarantee both maternal and fetal health …

Background People exposed to prolonged chronic unpredictable mild stress (CUMS) are
easy to suffer from depression and cognitive impairment. Environmental enrichment (EE) …

Agomelatine is a selective agonist of melatonin receptor 1A/melatonin receptor 1B (MT 1/MT
2) and antagonist of 5-hydroxytryptamine 2C receptors. It is used clinically to treat major …