Bone physiology as inspiration for tissue regenerative therapies
D Lopes, C Martins-Cruz, MB Oliveira, JF Mano - Biomaterials, 2018 - Elsevier
The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …
human body comprise a set of intricate and finely coordinated processes. However, an …
Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
In situ expansion, differentiation, and electromechanical coupling of human cardiac muscle in a 3D bioprinted, chambered organoid
Rationale: One goal of cardiac tissue engineering is the generation of a living, human pump
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …
[HTML][HTML] Generation of functional human pancreatic β cells in vitro
FW Pagliuca, JR Millman, M Gürtler, M Segel… - Cell, 2014 - cell.com
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide
an unprecedented cell source for drug discovery and cell transplantation therapy in …
an unprecedented cell source for drug discovery and cell transplantation therapy in …
Mechanism of regulation of stem cell differentiation by matrix stiffness
H Lv, L Li, M Sun, Y Zhang, L Chen, Y Rong… - Stem cell research & …, 2015 - Springer
Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …
Engineering immunomodulatory biomaterials for type 1 diabetes
CL Stabler, Y Li, JM Stewart… - Nature Reviews Materials, 2019 - nature.com
A cure for type 1 diabetes (T1D) would help millions of people worldwide but remains
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …
[HTML][HTML] Proteomic analysis of decellularized pancreatic matrix identifies collagen V as a critical regulator for islet organogenesis from human pluripotent stem cells
In pancreatic tissue engineering, generating human pancreatic islet organoids from stem
cells has been challenging due mainly to a poor understanding of niches required for …
cells has been challenging due mainly to a poor understanding of niches required for …
Lineage-specific exosomes could override extracellular matrix mediated human mesenchymal stem cell differentiation
Lineage specification is an essential process in stem cell fate, tissue homeostasis and
development. Microenvironmental cues provide direct and selective extrinsic signals to …
development. Microenvironmental cues provide direct and selective extrinsic signals to …
[HTML][HTML] Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies
L Jiang, Y Shen, Y Liu, L Zhang, W Jiang - Theranostics, 2022 - ncbi.nlm.nih.gov
Diabetes is one of the most socially challenging health concerns. Even though islet
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …
Nanotechnology in cell replacement therapies for type 1 diabetes
Islet transplantation is a promising long-term, compliance-free, complication-preventing
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …