Cellular redox, cancer and human papillomavirus

A Cruz-Gregorio, J Manzo-Merino, M Lizano - Virus Research, 2018 - Elsevier
Abstract High-risk Human Papillomavirus (HR-HPV) is the causative agent of different
human cancers. A persistent HR-HPV infection alters several cellular processes involved in …

Structural insights in multifunctional papillomavirus oncoproteins

I Suarez, G Trave - Viruses, 2018 - mdpi.com
Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7
have been recalcitrant to high-resolution structure analysis. However, in the last decade a …

Redox‐sensitive signalling pathways regulated by human papillomavirus in HPV‐related cancers

A Cruz‐Gregorio… - Reviews in Medical …, 2021 - Wiley Online Library
High‐risk human papillomavirus (HR‐HPV) chronic infection is associated with the induction
of different HPV‐related cancers, such as cervical, anus, vaginal, vulva, penis and …

Conserved cysteine-switches for redox sensing operate in the cyclin-dependent kinase inhibitor p21 (CIP/KIP) protein family

L Montero, YV Okraine, J Orlowski, S Matzkin… - Free Radical Biology …, 2024 - Elsevier
The cell cycle is a tightly regulated, dynamic process controlled by multiple checkpoints.
When the prevention of cell cycle progression is needed, key effectors such as members of …

[HTML][HTML] Interplay between sequence, structure and linear motifs in the adenovirus E1A hub protein

J Glavina, EA Román, R Espada, G de Prat-Gay… - Virology, 2018 - Elsevier
E1A is the main transforming protein in mastadenoviruses. This work uses bioinformatics to
extrapolate experimental knowledge from Human adenovirus serotype 5 and 12 E1A …

Topology dictates evolution of regulatory cysteines in a family of viral oncoproteins

D Alvarez-Paggi, JR Lorenzo… - Molecular Biology …, 2019 - academic.oup.com
Redox regulation in biology is largely operated by cysteine chemistry in response to a
variety of cell environmental and intracellular stimuli. The high chemical reactivity of …

Oxidative stress and thiol/disulfide homeostasis in human papillomavirus infections

S Sener, F Kilinc, A Akbas, S Erdogan… - Indian Journal of …, 2022 - journals.lww.com
Aim: This study aimed to investigate the role of oxidative stress in patients with HPV infection
by analyzing native thiol/disulfide homeostasis. Material and Methods: Forty-two patients …

Evaluation of dynamic thiol-disulfide homeostasis on HPV positive-women in progression to cervical intraepithelial lesion

R Erin, YB Tekin, H Küçük, Ö Erel - Journal of Experimental and …, 2021 - dergipark.org.tr
Objective: Dynamic thiol disulfide homeostasis (TDH) is critical in cervical carcinogenesis at
HPV infection as a sign of antioxidant consumption native and total thiol levels decrease in …