Computational methods for electron tomography

JJ Fernandez - Micron, 2012 - Elsevier
Electron tomography (ET) has emerged as a powerful technique to address fundamental
questions in molecular and cellular biology. It makes possible visualization of the molecular …

PyTom: a python-based toolbox for localization of macromolecules in cryo-electron tomograms and subtomogram analysis

T Hrabe, Y Chen, S Pfeffer, LK Cuellar… - Journal of structural …, 2012 - Elsevier
Cryo-electron tomography (CET) is a three-dimensional imaging technique for structural
studies of macromolecules under close-to-native conditions. In-depth analysis of …

[HTML][HTML] Protein secondary structure determination by constrained single-particle cryo-electron tomography

A Bartesaghi, F Lecumberry, G Sapiro, S Subramaniam - Structure, 2012 - cell.com
Cryo-electron microscopy (cryo-EM) is a powerful technique for 3D structure determination
of protein complexes by averaging information from individual molecular images. The …

A 3D image filter for parameter-free segmentation of macromolecular structures from electron tomograms

RA Ali, MJ Landsberg, E Knauth, GP Morgan… - PLoS …, 2012 - journals.plos.org
3D image reconstruction of large cellular volumes by electron tomography (ET) at high (≤ 5
nm) resolution can now routinely resolve organellar and compartmental membrane …

Structural studies of signal transduction in bacterial chemotaxis and a metabolism-related cancer target

M Venkatesh - 2015 - ora.ox.ac.uk
Transmission electron microscopy (TEM) has had a growing impact on the life sciences as
both technological and methodological developments have allowed for cells and …

Computational Analysis of the Spatial and Temporal Organization of the Cellular Environment

ZC Frazier - 2015 - search.proquest.com
Cellular processes take place over relatively large temporal and spatial scales. Molecular
interactions mediate structural changes in proteins and their complexes, which modulate …