Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Chronic inflammation underlies various debilitating disorders including autoimmune,
neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant …

The role of glutathione in autism spectrum disorder (ASD) is emerging as a major topic, due
to its role in the maintenance of the intracellular redox balance. Several studies have …

Prostanoids are cyclic, oxygenated products ofω3 andω6 20-and 22-carbon essential fatty
acids (FAs) that are formed enzymatically through “cyclooxygenases”. Prostaglandin …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

Foxp3+ regulatory T cells (Treg cells) are the central component of peripheral immune
tolerance. Whereas a dysregulated Treg cytokine signature has been observed in …

Lipids are essential for cellular functioning considering their role in membrane composition,
signaling, and energy metabolism. The brain is the second most abundant organ in terms of …

Lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids,
thereby contributing to the generation of various bioactive lipid mediators. Although 12/15 …

“Lipid mediators” represent a class of bioactive lipids that are produced locally through
specific biosynthetic pathways in response to extracellular stimuli. They are exported …