The dimeric transcription factor nuclear factor κB (NF‐κB) functions broadly in coordinating
cellular responses during inflammation and immune reactions, and its importance in the …

The inhibitory kappa B kinases (IKKs) are well recognized as key regulators of the nuclear
factor kappa B (NF‐κB) cascade and as such represent a point of convergence for many …

Objective Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the
pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the …

Sirtuin-1 (SIRT1), NAD+-dependent deacetylase, has been linked to anabolic effects in
cartilage, although the mechanisms of SIRT1 signaling during differentiation of …

Endocrine therapy is a commonly used treatment for estrogen receptor (ER)-positive breast
cancer. Although endocrine therapy has a favorable outcome in many patients, development …

Inhibitors of poly (ADP-ribose) polymerase (PARP) are promising anticancer drugs,
particularly for the treatment of tumors deficient in the DNA damage response (DDR) …

The inhibitory kappa B kinases (IKKs) and IKK related kinases are crucial regulators of the
pro-inflammatory transcription factor, nuclear factor kappa B (NF-κB). The dysregulation in …

Background It has been demonstrated previously that induced pluripotent stem cell (iPSC)-
derived mesenchymal stem cells (MSCs) have immunosuppressive effects on activated T …

Nitrosourea represents one of the most active classes of chemotherapeutic alkylating agents
for metastatic melanoma. Treatment with nitrosoureas caused severe systemic side effects …

Malignancies from the salivary glands are rare and represent 11% of all cancers from the
oropharyngeal anatomical area. Mucoepidermoid Carcinomas (MEC) is the most common …