The rat has been used extensively as a model for evaluating chemical toxicities and for
understanding drug mechanisms. However, its transcriptome across multiple organs, or …

Optimal pharmacotherapy is determined when the pharmacokinetics and
pharmacodynamics of the drug are understood. However, the age‐related changes in …

Purpose Preclinical studies suggest a potential protective effect of oleuropein in
osteoporosis, and one of the proposed mechanisms is the modulation of the oxidative stress …

Acute liver failure (ALF) is a life‐threatening disorder of liver function. Kynurenic acid
(KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway …

Studies in human and mammalian cell cultures have shown that induction of DNA repair
mechanisms is required for the formation of stimulation effects of low doses of ionizing …

Background Age-and sex-related susceptibility to adverse drug reactions and disease is a
key concern in understanding drug safety and disease progression. We hypothesize that the …

There is a need to characterize the potential susceptibility of older adults to toxicity from
environmental chemical exposures. Liver xenobiotic metabolizing enzymes (XMEs) play …

The use of gene expression profiling in both clinical and laboratory settings would be
enhanced by better characterization of variation due to individual, environmental, and …

Aging is associated with a loss of cellular homeostasis, a decline in physiological function
and an increase in various pathologies. Employing a meta-analysis, hepatic gene …

The present study was designed to fully uncover sex and circadian modulatory effects on rat
liver. Hepatic transcriptome analyses were performed at 4 hr intervals of a day-night cycle …