Nanodevices for deep cartilage penetration

XL Xu, Y Xue, JY Ding, ZH Zhu, XC Wu, YJ Song… - Acta Biomaterialia, 2022 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease and is the main cause of chronic pain and
functional disability in adults. Articular cartilage is a hydrated soft tissue that is composed of …

Regulating Chondro‐Bone Metabolism for Treatment of Osteoarthritis via High‐Permeability Micro/Nano Hydrogel Microspheres

G Zuo, P Zhuang, X Yang, Q Jia, Z Cai, J Qi… - Advanced …, 2024 - Wiley Online Library
Destruction of cartilage due to the abnormal remodeling of subchondral bone (SB) leads to
osteoarthritis (OA), and restoring chondro‐bone metabolic homeostasis is the key to the …

Designing smart microcapsules with natural polyelectrolytes to improve self-healing performance for water-based polyurethane coatings

B Li, D Njuko, M Meng, A Tang, Y Li - ACS Applied Materials & …, 2022 - ACS Publications
Active anticorrosive organic coatings adopting microcapsules (MCs) have lately attracted
extensive attention as they were proven to be effective to minimize metal corrosions and …

[HTML][HTML] Engineering gene-activated bioprinted scaffolds for enhancing articular cartilage repair

M Wang, J Wang, X Xu, E Li, P Xu - Materials Today Bio, 2024 - Elsevier
Untreated articular cartilage injuries often result in severe chronic pain and dyskinesia.
Current repair strategies have limitations in effectively promoting articular cartilage repair …

Identification and comprehensive analysis of circRNA–miRNA–mRNA regulatory networks in osteoarthritis

X Liu, H Xiao, X Peng, Y Chai, S Wang… - Frontiers in …, 2023 - frontiersin.org
Osteoarthritis (OA) is a common orthopedic degenerative disease, leading to high disability
in activities of daily living. There remains an urgent need to identify the underlying …

Fatty acid metabolism and C9 aldehyde biosynthesis are involved in ε-poly-l-lysine-induced citrus fruit resistance to Penicillium digitatum

X Zhang, Q Deng, X Gao, W Wang, K Zeng - Pesticide Biochemistry and …, 2023 - Elsevier
Citrus fruit were easily infected by Penicillium digitatum, and caused green mold rapidly,
resulting in enormous post-harvest losses. ε-poly-l-lysine (ε-PL) was generally regarded as a …

[HTML][HTML] Cartilage-targeted drug nanocarriers for osteoarthritis therapy

L Morici, E Allémann, C Rodríguez-Nogales… - International Journal of …, 2024 - Elsevier
Osteoarthritis (OA) is a joint disease common worldwide. Currently, no disease-modifying
osteoarthritis drugs (DMOADs) have successfully passed clinical trials, often due to a lack of …

Branched poly‐l‐lysine for cartilage penetrating carriers

G Gonzales, J Hoque, A Gilpin, B Maity… - Bioengineering & …, 2024 - Wiley Online Library
Joint diseases, such as osteoarthritis, often require delivery of drugs to chondrocytes
residing within the cartilage. However, intra‐articular delivery of drugs to cartilage remains a …

Efficacy of EDTA-NS irrigation in eradicating Staphylococcus aureus biofilm-associated infection: an in vitro and in vivo study

J Lin, J Suo, B Bao, H Wei, T Gao, H Zhu… - Bone & Joint …, 2024 - boneandjoint.org.uk
Aims To investigate the efficacy of ethylenediaminetetraacetic acid-normal saline (EDTA-
NS) in dispersing biofilms and reducing bacterial infections. Methods EDTA-NS solutions …

Synthesis and comparison of cationic polymers for structural effects of backbones and grafted side chains on their DNA transfection for efficient gene delivery

TY Hou, KH Pan, MF Shih, JY Cherng - Polymer International, 2024 - Wiley Online Library
Many cationic polymers with varied architectures either in backbones or in side chains have
been used for gene delivery. However, these polymers yielding different DNA transfection …