Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

D Ezhilarasan - Toxicology, 2021 - Elsevier
Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …

Protective effects of flavonoids against Alzheimer's disease: pathological hypothesis, potential targets, and structure–activity relationship

J Li, M Sun, X Cui, C Li - International Journal of Molecular Sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease with high morbidity and mortality,
for which there is no available cure. Currently, it is generally believed that AD is a disease …

Progress in the treatment of drug-induced liver injury with natural products

Y Sun, Y Zhang, L Xie, F Rong, X Zhu, J Xie… - Pharmacological …, 2022 - Elsevier
There are numerous prescription drugs and non-prescription drugs that cause drug-induced
liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its …

Busting the myth of methotrexate chronic hepatotoxicity

V Di Martino, DW Verhoeven, F Verhoeven… - Nature Reviews …, 2023 - nature.com
Methotrexate is a key component of the treatment of inflammatory rheumatic diseases and
the mainstay of therapy in rheumatoid arthritis. Hepatotoxicity has long been a concern for …

Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats

B Varışlı, C Caglayan, FM Kandemir, C Gür… - Molecular Biology …, 2023 - Springer
Background Diclofenac (DF) is a non-steroidal anti-inflammatory drug (NSAID) generally
prescribed for the treatment of pain. In spite of the widespread use of DF, hepatotoxicity has …

Apigenin ameliorates di (2-ethylhexyl) phthalate-induced ferroptosis: The activation of glutathione peroxidase 4 and suppression of iron intake

D Han, Y Yao, L Chen, Z Miao, S Xu - Food and Chemical Toxicology, 2022 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a widely artificial persistent organic pollutant,
the contamination of which infiltrates daily human life from many aspects, imperceptibly …

Upregulation of Nrf2/HO-1 signaling and attenuation of oxidative stress, inflammation, and cell death mediate the protective effect of apigenin against …

W Al-Amarat, MH Abukhalil, RS Alruhaimi, HA Alqhtani… - Metabolites, 2022 - mdpi.com
Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide
(CP). This study investigated the protective role of the flavone apigenin (API) against CP …

Dietary polyphenols alleviate autoimmune liver disease by mediating the intestinal microenvironment: Challenges and hopes

Z Cheng, Y Wang, B Li - Journal of Agricultural and Food …, 2022 - ACS Publications
Autoimmune liver disease is a chronic liver disease caused by an overactive immune
response in the liver that imposes a significant health and economic cost on society. Due to …

[HTML][HTML] Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury

VR de Porras, M Figols, A Font, E Pardina - Life Sciences, 2023 - Elsevier
Despite significant advances in cancer therapeutics, chemotherapy remains the cornerstone
of treatment for many tumors. Importantly, however, chemotherapy-induced toxicity …

Spirulina and thymoquinone protect against methotrexate-induced hepatic injury in rats

A Behairy, A Elkomy, F Elsayed, MMS Gaballa… - Revista Brasileira de …, 2024 - Springer
Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer.
The purpose of this research was to examine if the administration of Arthrospira platensis …