In late 1993 and early 1994, two distinct lines of research converged on a new tumor
suppressor gene located on human chromosome 9p21. The órst report was of the existence …

Publisher Summary As normal cells progress to tumorigenicity, they must develop two
distinct new characteristics not possessed by the normal cells from which they arise: they …

Neoplastic diseases are characterized by uncoordinated cell growth. Cellular proliferation
follows an orderly progression through the cell cycle, which is governed by protein …

Human gastric carcinoma shows a higher prevalence of microsatellite instability (MSI) than
does any other type of sporadic human cancer. The reasons for this high frequency of MSI …

A critical area ofchromosomal loss at region 9p2 1-22 has been implicated in the genesis of
different types of primary tumors. Initial observations defined dele-tions of this region in …

Fibroblast growth factor receptor 3 (FGFR3) and P53 mutations are frequently observed in
bladder cancer. We here describe the distribution of FGFR3 mutations and P53 …

Twelve to 15% of sporadic colorectal cancers display defective DNA mismatch repair
(MMR), manifested as microsatellite instability (MSI). In this group of cancers, promoter …

We have investigated by RNase protection analysis the expression of 2 angiogenic factors
in 45 primary bladder tumors and 8 normal bladders. Expression of vascular endothelial …

Aim: This is a narrative review with an aim to summarise and describe urinary biomarkers in
the surveillance of non-muscle-invasive bladder cancer (NMIBC). It provides a summary of …

Human transitional cell carcinomas of the bladder frequently reveal chromosomal
abnormalities that span a range between chromosome 9p12 and 9qter, even at early stages …