Cell type–specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis
Schizophrenia (SCZ) is a chronic, serious mental disorder. Although more than 200 SCZ-
associated genes have been identified, the underlying molecular and cellular mechanisms …
associated genes have been identified, the underlying molecular and cellular mechanisms …
Syntaxin 1B mediates berberine's roles in epilepsy-like behavior in a pentylenetetrazole-induced seizure zebrafish model
YM Zheng, B Chen, JD Jiang, JP Zhang - Frontiers in Molecular …, 2018 - frontiersin.org
Epilepsy is a neuronal dysfunction syndrome characterized by transient and diffusely
abnormal discharges of neurons in the brain. Previous studies have shown that mutations in …
abnormal discharges of neurons in the brain. Previous studies have shown that mutations in …
Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature‐dependent seizures
T Mishima, T Fujiwara, T Kofuji, A Saito… - Journal of …, 2021 - Wiley Online Library
De novo heterozygous mutations in the STX1B gene, encoding syntaxin 1B, cause a
familial, fever‐associated epilepsy syndrome. Syntaxin 1B is an essential component of the …
familial, fever‐associated epilepsy syndrome. Syntaxin 1B is an essential component of the …
Association of three candidate genetic variants in ACMSD/TMEM163, GPNMB and BCKDK/STX1B with sporadic Parkinson's disease in Han Chinese
L Wang, N Li, ZJ Lu, JY Li, JX Peng, LR Duan… - Neuroscience …, 2019 - Elsevier
Large-scale meta-analyses of genome-wide association studies have identified that
polymorphisms ACMSD/TMEM163 rs6430538, GPNMB rs199347 and BCKDK/STX1B …
polymorphisms ACMSD/TMEM163 rs6430538, GPNMB rs199347 and BCKDK/STX1B …
Disturbance of the reciprocal-interaction between the OXTergic and DAergic systems in the CNS causes atypical social behavior in syntaxin 1A knockout mice
T Fujiwara, T Kofuji, K Akagawa - Behavioural Brain Research, 2021 - Elsevier
Several studies have shown that oxytocin (OXT) modulates social behavior. Similarly,
monoamines such as dopamine (DA) play a role in regulating social behavior. Previous …
monoamines such as dopamine (DA) play a role in regulating social behavior. Previous …
Knockdown of piccolo in the nucleus accumbens suppresses methamphetamine-induced hyperlocomotion and conditioned place preference in mice
Y Kusui, N Izuo, K Uno, B Ge, S Muramatsu… - Neurochemical …, 2022 - Springer
Methamphetamine (METH), the most widely distributed psychostimulant, aberrantly activates
the reward system in the brain to induce addictive behaviors. The presynaptic protein …
the reward system in the brain to induce addictive behaviors. The presynaptic protein …
A PRRT2 variant in a Chinese family with paroxysmal kinesigenic dyskinesia and benign familial infantile seizures results in loss of interaction with STX1B
H Ma, S Feng, X Deng, L Wang, S Zeng, C Wang… - …, 2018 - Wiley Online Library
Objective To identify the causative gene of autosomal dominant paroxysmal kinesigenic
dyskinesia and benign familial infantile seizures (PKD/BFIS) in a large Chinese family and …
dyskinesia and benign familial infantile seizures (PKD/BFIS) in a large Chinese family and …
[PDF][PDF] THE NEURODEGENERATION PROCESS IN THE STRIATUM OF MICE EXPOSED TO OBESOGENIC DIETS
A Talukdar - 2020 - lup.lub.lu.se
Obesity and diabetes are known to impact brain function and alter metabolism. Studies in
rodents show that consumption of high fat and high sugar diets lead to brain dysfunction …
rodents show that consumption of high fat and high sugar diets lead to brain dysfunction …
Advancing Clinical Outcomes, Biomarkers, and Treatments for Severe TBI
T Pape - 2021 - apps.dtic.mil
This study is a double-blind randomized placebo-controlled clinical trial using repeated
measures. The objective is to improve recovery of functional skills for persons living in states …
measures. The objective is to improve recovery of functional skills for persons living in states …