Biomechanical properties of red blood cells in health and disease towards microfluidics

G Tomaiuolo - Biomicrofluidics, 2014 - pubs.aip.org
Red blood cells (RBCs) possess a unique capacity for undergoing cellular deformation to
navigate across various human microcirculation vessels, enabling them to pass through …

Methods to investigate the deformability of RBC during malaria

M Depond, B Henry, P Buffet, PA Ndour - Frontiers in physiology, 2020 - frontiersin.org
Despite a 30% decline in mortality since 2000, malaria still affected 219 million subjects and
caused 435,000 deaths in 2017. Red blood cells (RBC) host Plasmodium parasites that …

Assessing red blood cell deformability from microscopy images using deep learning

ES Lamoureux, E Islamzada, MVJ Wiens, K Matthews… - Lab on a Chip, 2022 - pubs.rsc.org
Red blood cells (RBCs) must be highly deformable to transit through the microvasculature to
deliver oxygen to tissues. The loss of RBC deformability resulting from pathology, natural …

Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion

Y Man, D Maji, R An, SP Ahuja, JA Little, MA Suster… - Lab on a Chip, 2021 - pubs.rsc.org
Alterations in the deformability of red blood cells (RBCs), occurring in hemolytic blood
disorders such as sickle cell disease (SCD), contribute to vaso-occlusion and disease …

[HTML][HTML] Measuring deformability and red cell heterogeneity in blood by ektacytometry

NL Parrow, PC Violet, H Tu, J Nichols… - Journal of visualized …, 2018 - ncbi.nlm.nih.gov
Decreased red cell deformability is characteristic of several disorders. In some cases, the
extent of defective deformability can predict severity of disease or occurrence of serious …

Deformability based sorting of stored red blood cells reveals donor-dependent aging curves

E Islamzada, K Matthews, Q Guo, AT Santoso… - Lab on a Chip, 2020 - pubs.rsc.org
A fundamental challenge in the transfusion of red blood cells (RBCs) is that a subset of
donated RBC units may not provide optimal benefit to transfusion recipients. This variability …

Characterization of red blood cell deformability change during blood storage

Y Zheng, J Chen, T Cui, N Shehata, C Wang, Y Sun - Lab on a Chip, 2014 - pubs.rsc.org
Stored red blood cells (RBCs) show progressive deformability changes during blood
banking/storage. Their deformability changes over an 8 weeks' storage period were …

Deformability analysis of sickle blood using ektacytometry

M Rabai, JA Detterich, RB Wenby… - …, 2014 - content.iospress.com
Sickle cell disease (SCD) is characterized by decreased erythrocyte deformability,
microvessel occlusion and severe painful infarctions of different organs. Ektacytometry of …

Human red blood cell membrane stiffness: why should we study it and how?

R Selvan, S Bhattacharya - The European Physical Journal Special Topics, 2024 - Springer
The primary function of the human red blood cells (RBCs) is to transport oxygen to all tissues
in the human body for the process of cellular respiration. To do this, RBCs often need to …

Biophysical profiling of red blood cells from thin-film blood smears using deep learning

ES Lamoureux, Y Cheng, E Islamzada, K Matthews… - Heliyon, 2024 - cell.com
Microscopic inspection of thin-film blood smears is widely used to identify red blood cell
(RBC) pathologies, including malaria parasitism and hemoglobinopathies, such as sickle …