Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands

S Cecioni, A Imberty, S Vidal - Chemical reviews, 2015 - ACS Publications
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …

Multivalent glycosystems for human lectins

M Martínez-Bailén, J Rojo… - Chemical Society …, 2023 - pubs.rsc.org
Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …

Lipid-based mRNA vaccine delivery systems

P Midoux, C Pichon - Expert review of vaccines, 2015 - Taylor & Francis
Synthetic mRNAs can become biopharmaceutics allowing vaccination against cancer,
bacterial and virus infections. Clinical trials with direct administration of synthetic mRNAs …

Synthesis of highly efficient multivalent disaccharide/[60] fullerene nanoballs for emergent viruses

J Ramos-Soriano, JJ Reina, BM Illescas… - Journal of the …, 2019 - ACS Publications
After the last epidemic of the Zika virus (ZIKV) in Brazil that peaked in 2016, growing
evidence has been demonstrated of the link between this teratogenic flavivirus and …

Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

L Mydock-McGrane, Z Cusumano, Z Han… - Journal of medicinal …, 2016 - ACS Publications
Gram-negative uropathogenic Escherichia coli (UPEC) bacteria are a causative pathogen of
urinary tract infections (UTIs). Previously developed antivirulence inhibitors of the type 1 …

[HTML][HTML] Identification of a new DC-SIGN binding pentamannoside epitope within the complex structure of Candida albicans mannan

VB Krylov, M Gómez-Redondo, AS Solovev… - The Cell Surface, 2023 - Elsevier
The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-
SIGN) is an innate immune C-type lectin receptor that recognizes carbohydrate-based …

A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

N Varga, I Sutkeviciute, R Ribeiro-Viana, A Berzi… - Biomaterials, 2014 - Elsevier
Abstract DC-SIGN is a C-type lectin receptor on antigen presenting cells (dendritic cells)
which has an important role in some viral infection, notably by HIV and Dengue virus (DV) …

[PDF][PDF] Targeting the C-type lectins-mediated host-pathogen interactions with dextran

S Pustylnikov, D Sagar, P Jain… - Journal of Pharmacy & …, 2014 - frontierspartnerships.org
Dextran, the α-1, 6-linked glucose polymer widely used in biology and medicine, promises
new applications. Linear dextran applied as a blood plasma substitute demonstrates a high …

Plant lectins and their usage in preparing targeted nanovaccines for cancer immunotherapy

B Gupta, D Sadaria, VU Warrier, A Kirtonia… - Seminars in Cancer …, 2022 - Elsevier
Plant lectins, a natural source of glycans with a therapeutic potential may lead to the
discovery of new targeted therapies. Glycans extracted from plant lectins are known to act as …