The retinoblastoma tumor suppressor protein Rb plays a major role in regulating G1/S
transition and is a critical regulator of cell proliferation. Rb protein exerts its growth …

In mammalian cells, E2F family of transcription factors (E2Fs) traditionally modulates
assorted cellular functions related to cell cycle progression, proliferation, apoptosis and …

E2F transcription factors are involved in cell cycle regulation and synthesis of DNA in
mammalian cells, and simultaneously play important roles in the development and …

Disorganized vessels in the tumor vasculature lead to impaired perfusion, resulting in
reduced accessibility to immune cells and chemotherapeutic drugs. In the breast tumor …

Purpose: HIF2α is a key driver of kidney cancer. Using a belzutifan analogue (PT2399), we
previously showed in tumorgrafts (TG) that∼ 50% of clear cell renal cell carcinomas …

E2F transcriptional factors are widely expressed in a number of tissues and organs,
possessing many regulatory functions related to cellular proliferation, differentiation, DNA …

We intended to evaluate miR‐490‐5p expression in hepatocellular carcinoma (HCC) tissues
and detect the potential targets of miR‐490‐5p. In vitro experiments were conducted to …

The CDK4/6 inhibitor palbociclib reduces tumor growth by decreasing retinoblastoma (RB)
protein phosphorylation and inducing cell cycle arrest at the G1/S phase transition …

Peptidyl prolyl isomerase (PIN1) regulates the functional activity of a subset of
phosphoproteins through binding to phosphorylated Ser/Thr-Pro motifs and subsequently …

Background: Despite the recent research implicating E2F8 (E2F Transcription Factor 8) in
cancer, the role of E2F8 in the progression of ovarian cancer has remained unclear. Hence …