Biochemistry of peroxynitrite and protein tyrosine nitration

G Ferrer-Sueta, N Campolo, M Trujillo… - Chemical …, 2018 - ACS Publications
Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

The superoxide radical switch in the biology of nitric oxide and peroxynitrite

L Piacenza, A Zeida, M Trujillo… - Physiological …, 2022 - journals.physiology.org
The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

[HTML][HTML] Interplay between oxidant species and energy metabolism

C Quijano, M Trujillo, L Castro, A Trostchansky - Redox biology, 2016 - Elsevier
It has long been recognized that energy metabolism is linked to the production of reactive
oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by …

iNOS as a metabolic enzyme under stress conditions

S Anavi, O Tirosh - Free Radical Biology and Medicine, 2020 - Elsevier
Nitric oxide (NO) is a free radical acting as a cellular signaling molecule in many different
biochemical processes. NO is synthesized from l-arginine through the action of the nitric …

Peroxiredoxins in plants and cyanobacteria

KJ Dietz - Antioxidants & redox signaling, 2011 - liebertpub.com
I. Introduction II. Classification of Plant Prxs and Their Distribution in Plants and
Cyanobacteria III. Peroxidase Activity of Peroxiredoxins IV. Conformational Dynamics and …

[HTML][HTML] Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

A Daiber - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2010 - Elsevier
This review highlights the important role of redox signaling between mitochondria and
NADPH oxidases. Besides the definition and general importance of redox signaling, the …

Features and regulation of non-enzymatic post-translational modifications

R Harmel, D Fiedler - Nature chemical biology, 2018 - nature.com
Non-enzymatic post-translational modifications of proteins can occur when a nucleophilic or
redox-sensitive amino acid side chain encounters a reactive metabolite. In many cases, the …

Reactive oxygen and nitrogen species and functional adaptation of the placenta

L Myatt - Placenta, 2010 - Elsevier
The placenta regulates fetal growth and development via transport of nutrients and gases,
and synthesis and secretion of steroid and peptide hormones. These functions are …

Protein tyrosine nitration—functional alteration or just a biomarker?

JM Souza, G Peluffo, R Radi - Free Radical Biology and Medicine, 2008 - Elsevier
Protein 3-nitrotyrosine is a posttranslational modification found in many pathological
conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the …

Alterations of cellular bioenergetics in pulmonary artery endothelial cells

W Xu, T Koeck, AR Lara, D Neumann… - Proceedings of the …, 2007 - National Acad Sciences
Idiopathic pulmonary arterial hypertension (IPAH) is pathogenetically related to low levels of
the vasodilator nitric oxide (NO). Because NO regulates cellular respiration and …