RNA modification: mechanisms and therapeutic targets
L Qiu, Q Jing, Y Li, J Han - Molecular Biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …
that are regulated by specific modifying enzymes. They play important roles in the regulation …
[HTML][HTML] Detailed resume of RNA m6A demethylases
D Shen, B Wang, Y Gao, L Zhao, Y Bi, J Zhang… - … pharmaceutica Sinica B, 2022 - Elsevier
Abstract N6-Methyladenosine (m 6 A) is the most abundant internal modification in
eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic …
eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic …
[HTML][HTML] Targeting FTO suppresses cancer stem cell maintenance and immune evasion
Fat mass and obesity-associated protein (FTO), an RNA N 6-methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia
FTO, an mRNA N 6-methyladenosine (m 6 A) demethylase, was reported to promote
leukemogenesis. Using structure-based rational design, we have developed two promising …
leukemogenesis. Using structure-based rational design, we have developed two promising …
Rational design of RNA demethylase FTO inhibitors with enhanced antileukemia drug-like properties
P Xiao, Z Duan, Z Liu, L Chen, D Zhang… - Journal of Medicinal …, 2023 - ACS Publications
The fat mass and obesity-associated protein (FTO) is an RNA N 6-methyladenosine (m6A)
demethylase highly expressed in diverse cancers including acute myeloid leukemia (AML) …
demethylase highly expressed in diverse cancers including acute myeloid leukemia (AML) …
Structure–activity relationships and antileukemia effects of the tricyclic benzoic acid FTO inhibitors
Z Liu, Z Duan, D Zhang, P Xiao, T Zhang… - Journal of Medicinal …, 2022 - ACS Publications
The N 6-methyladenosine (m6A) demethylase FTO is overexpressed in acute myeloid
leukemia (AML) cells and promotes leukemogenesis. We previously developed tricyclic …
leukemia (AML) cells and promotes leukemogenesis. We previously developed tricyclic …
Targeting the RNA demethylase FTO for cancer therapy
LL Zhou, H Xu, Y Huang, CG Yang - RSC chemical biology, 2021 - pubs.rsc.org
N 6-Methyladenosine (m6A) is the most prevalent internal modification on mRNA and
represents a new layer of gene expression in eukaryotes. The field of m6A-encoded …
represents a new layer of gene expression in eukaryotes. The field of m6A-encoded …
Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity
Here, we show that vitamin E succinate (VES) acts as a degrader for the m6A RNA
demethylase fat mass and obesity-associated protein (FTO), thus suppressing tumor growth …
demethylase fat mass and obesity-associated protein (FTO), thus suppressing tumor growth …
Plant-based analogues identified as potential inhibitor against tobacco mosaic virus: A biosimulation approach
Benzosuberene compounds with a pyrrolone group adhered to it are compounds extracted
from the oils of Cedrus deodara plant, that bear inhibitory capabilities. Tobacco mosaic virus …
from the oils of Cedrus deodara plant, that bear inhibitory capabilities. Tobacco mosaic virus …
Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies
Abstract Background Annona muricata (Annonaceae) known as soursop is a common
tropical plant species known for its numerous medicinal properties including obesity. The …
tropical plant species known for its numerous medicinal properties including obesity. The …