G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors, are
the largest family of cell surface receptors in eukaryotes. There are∼ 800 GPCRs in human …

Rapid flip-flop of phospholipids across the two leaflets of biological membranes is crucial for
many aspects of cellular life. The transport proteins that facilitate this process are classified …

Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic
receptors to target and lyse cancer cells. CARs bind to cell surface antigens through an scFv …

Class AG protein-coupled receptors (GPCRs), a superfamily of cell membrane signaling
receptors, moonlight as constitutively active phospholipid scramblases. The plasma …

Retinitis pigmentosa (RP) is a hereditary disease characterized by progressive vision loss
ultimately leading to blindness. This condition is initiated by mutations in genes expressed in …

Membrane proteins are often observed as higher-order oligomers, and in some cases in
multiple stoichiometric forms, raising the question of whether dynamic oligomerization can …

Cancer immunotherapy is a general therapeutic approach which directs the body's immune
system to kill cancer. Such therapies have had considerable clinical success, but their …