Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple
organs and are characterized by hyperglycaemia. Currently, stable and effective treatments …

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs
and maintain an individual's health. The liver has a major role in the control of glucose …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is
important for very low-density lipoprotein (VLDL) production and thus energy distribution to …

The immunological process of clonal selection requires a rapid burst in lymphocyte
proliferation, and this involves a metabolic shift to provide energy and the building blocks of …

Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which
transcriptionally activates genes involved in FA synthesis, whereas glucose activates …

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated.
Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis …

Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has
long been categorized as a housekeeping protein, producing fat for storage of energy when …

Nonalcoholic fatty liver disease (NAFLD) is associated with all features of the metabolic
syndrome. Although deposition of excess triglycerides within liver cells, a hallmark of …