The computational metabolomics field brings together computer scientists, bioinformaticians,
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …

Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …

Post-infectious conditions present major health burdens but remain poorly understood. In
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …

As privileged structures, natural products often display potent biological activities. However,
the discovery of novel bioactive scaffolds is often hampered by the chemical complexity of …

The repertoire of modifications to bile acids and related steroidal lipids by host and microbial
metabolism remains incompletely characterized. To address this knowledge gap, we …

Lipids play a crucial role in cellular structure and functions, including cell signaling,
membrane plasticity, and trafficking. Alterations of the lipid composition in cells, tissues, or …

Alzheimer's disease remains a global health challenge and an unmet need requiring
innovative approaches to discover new drugs. The current study aimed to investigate the …

Polyphenols, prevalent in plants and fungi, are investigated intensively in nutritional and
clinical settings because of their beneficial bioactive properties. Due to their complexity …

Wood-decaying fungi are the major decomposers of plant litter. Heavy sequencing efforts on
genomes of wood-decaying fungi have recently been made due to the interest in their …

A Sample-Centric and Knowledge-Driven Computational Framework for Natural Products Drug
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