From multi-omics approaches to precision medicine in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder,
caused by the degeneration of upper and lower motor neurons for which there is no truly …
caused by the degeneration of upper and lower motor neurons for which there is no truly …
iPSCs: A preclinical drug research tool for neurological disorders
G Bonaventura, R Iemmolo, GA Attaguile… - International journal of …, 2021 - mdpi.com
The development and commercialization of new drugs is an articulated, lengthy, and very
expensive process that proceeds through several steps, starting from target identification …
expensive process that proceeds through several steps, starting from target identification …
PACAP modulates the autophagy process in an in vitro model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of complex
etiology leading to motor neuron degeneration. Many gene alterations cause this pathology …
etiology leading to motor neuron degeneration. Many gene alterations cause this pathology …
Neuroprotective effect of the PACAP-ADNP axis on SOD1G93A mutant motor neuron death induced by trophic factors deprivation
Amyotrophic lateral Sclerosis (ALS) is a neurodegenerative disease characterized by
progressive degeneration of motor neurons in the central nervous system. Mutations in the …
progressive degeneration of motor neurons in the central nervous system. Mutations in the …
[HTML][HTML] Genomic and transcriptomic advances in amyotrophic lateral sclerosis
M Rizzuti, L Sali, V Melzi, S Scarcella… - Ageing Research …, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and the most common
motor neuron disease. ALS shows substantial clinical and molecular heterogeneity. In vitro …
motor neuron disease. ALS shows substantial clinical and molecular heterogeneity. In vitro …
Molecular mechanisms involved in the protective effect of pituitary adenylate cyclase‐activating polypeptide in an in vitro model of amyotrophic lateral sclerosis
G Maugeri, AG D'Amico, DM Rasà… - Journal of Cellular …, 2019 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the loss of upper and lower motor neurons. Based on transcriptional profiles of motor cortex …
the loss of upper and lower motor neurons. Based on transcriptional profiles of motor cortex …
Differential vulnerability of oculomotor versus hypoglossal nucleus during ALS: involvement of PACAP
Amyotrophic lateral sclerosis (ALS) is a progressive multifactorial disease characterized by
the loss of motor neurons (MNs). Not all MNs undergo degeneration: neurons of the …
the loss of motor neurons (MNs). Not all MNs undergo degeneration: neurons of the …
Splicing players are differently expressed in sporadic amyotrophic lateral sclerosis molecular clusters and brain regions
Splicing is a tightly orchestrated process by which the brain produces protein diversity over
time and space. While this process specializes and diversifies neurons, its deregulation may …
time and space. While this process specializes and diversifies neurons, its deregulation may …
[HTML][HTML] Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS
A plethora of genetic and molecular mechanisms have been implicated in the
pathophysiology of the heterogeneous and multifactorial amyotrophic lateral sclerosis (ALS) …
pathophysiology of the heterogeneous and multifactorial amyotrophic lateral sclerosis (ALS) …
The ε-Isozyme of Protein Kinase C (PKCε) Is Impaired in ALS Motor Cortex and Its Pulse Activation by Bryostatin-1 Produces Long Term Survival in Degenerating …
V La Cognata, AG D'Amico, G Maugeri… - International journal of …, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal
neurodegenerative disease, characterized by a progressive depletion of upper and lower …
neurodegenerative disease, characterized by a progressive depletion of upper and lower …