Obesity, adipose tissue and vascular dysfunction

M Koenen, MA Hill, P Cohen, JR Sowers - Circulation research, 2021 - Am Heart Assoc
Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

CR Kahn, G Wang, KY Lee - The Journal of clinical …, 2019 - Am Soc Clin Investig
Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …

Control of brown and beige fat development

W Wang, P Seale - Nature reviews Molecular cell biology, 2016 - nature.com
Brown and beige adipocytes expend chemical energy to produce heat and are therefore
important in regulating body temperature and body weight. Brown adipocytes develop in …

Brown and beige fat: development, function and therapeutic potential

M Harms, P Seale - Nature medicine, 2013 - nature.com
Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

Adipose tissue browning and metabolic health

A Bartelt, J Heeren - Nature Reviews Endocrinology, 2014 - nature.com
Accumulation of excess white adipose tissue (WAT) has deleterious consequences for
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues

V Pellegrinelli, S Carobbio, A Vidal-Puig - Diabetologia, 2016 - Springer
White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in
regulating energy homeostasis and insulin sensitivity. WAT is characterised by its capacity to …

The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

I AlZaim, LPMH de Rooij, BN Sheikh… - Nature Reviews …, 2023 - nature.com
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …

[HTML][HTML] Adipose tissue in control of metabolism

L Luo, M Liu - Journal of endocrinology, 2016 - joe.bioscientifica.com
Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …

AMP-activated protein kinase (AMPK) regulates energy metabolism through modulating thermogenesis in adipose tissue

L Wu, L Zhang, B Li, H Jiang, Y Duan, Z Xie… - Frontiers in …, 2018 - frontiersin.org
Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas
brown adipose tissue (BAT), which is specialized in dissipating energy through …

Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway

P Fu, R Zhu, J Jia, Y Hu, C Wu, P Cieszczyk… - Nutrition & …, 2021 - Springer
Background High-fat diet (HFD)-induced obesity causes immune cells to infiltrate adipose
tissue, leading to chronic inflammation and metabolic syndrome. Brown adipose tissue …