Current clinical practices focus on a small number of biochemical directly related to the
pathophysiology with patients and thus only describe a very limited metabolome of a patient …

Despite advances in surgery and adjuvant therapy, brain tumors represent one of the
leading causes of cancer‐related mortality and morbidity in both adults and children …

Assessment of a biological system by means of global and non-targeted metabolite profiling—
metabolomics or metabonomics—provides the investigator with molecular information that is …

Hypoxia has been recognized to play a role in promoting the invasive and metastatic
behaviour of cancer cells. Largely via the transcription factor, hypoxia-induced factor 1 …

This article focuses on the description of some of the NMR techniques used in the field of
biomedical and pharmaceutical research. Indeed, the NMR method has special …

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as
glioblastoma represents a potentially targetable vulnerability. Homozygous MTAP-deleted …

This work aims at characterizing the metabolic profile of human lung cancer, to gain new
insights into tumor metabolism and to identify possible biomarkers with potential diagnostic …

Biomarkers are molecular indicators of a biological status, and as biochemical species can
be assayed to evaluate the presence of cancer and therapeutic interventions. Through a …

High-resolution magic-angle spinning (HR-MAS) proton NMR spectroscopy is used to
explore the metabolic signatures of head and neck squamous cell carcinoma (HNSCC) …

One of the central hallmarks of cancer is the rapid and infinite cellular proliferation. In order
to cope with increased requirement for building blocks and energy, cancer cells develop …