Hydrogels as functional components in artificial cell systems

ME Allen, JW Hindley, DK Baxani, O Ces… - Nature Reviews …, 2022 - nature.com
Recent years have seen substantial efforts aimed at constructing artificial cells from various
molecular components with the aim of mimicking the processes, behaviours and …

Molecular cybernetics: challenges toward cellular chemical artificial intelligence

S Murata, T Toyota, SM Nomura… - Advanced Functional …, 2022 - Wiley Online Library
Research on so‐called “chemical artificial intelligence”(CAI) is an emerging field with the
aim of constructing information‐processing systems with learning capabilities based on …

Bottom-up assembly of synthetic cells with a DNA cytoskeleton

K Jahnke, V Huth, U Mersdorf, N Liu, K Göpfrich - ACS nano, 2022 - ACS Publications
Cytoskeletal elements, like actin and myosin, have been reconstituted inside lipid vesicles
toward the vision to reconstruct cells from the bottom up. Here, we realize the de novo …

Biomimetic behaviors in hydrogel artificial cells through embedded organelles

ME Allen, JW Hindley, N O'Toole… - Proceedings of the …, 2023 - National Acad Sciences
Artificial cells are biomimetic structures formed from molecular building blocks that replicate
biological processes, behaviors, and architectures. Of these building blocks, hydrogels have …

Computational DNA droplets recognizing miRNA sequence inputs based on liquid–liquid phase separation

J Gong, N Tsumura, Y Sato… - Advanced Functional …, 2022 - Wiley Online Library
Phase‐separated biomolecular droplets are formed in cells to regulate various biological
processes. This phenomenon can be applied to constructing self‐assembled dynamic …

DNA droplets: intelligent, dynamic fluid

H Udono, J Gong, Y Sato, M Takinoue - Advanced Biology, 2023 - Wiley Online Library
Breathtaking advances in DNA nanotechnology have established DNA as a promising
biomaterial for the fabrication of programmable higher‐order nano/microstructures. In the …

Spatial organization of phase-separated DNA droplets

S Wilken, A Chaderjian, OA Saleh - Physical Review X, 2023 - APS
Many recent studies of liquid-liquid phase separation in biology focus on phase separation
as a dynamic control mechanism for cellular function, but it can also result in complex …

DNA droplets for intelligent and dynamical artificial cells: From the viewpoint of computation and non-equilibrium systems

M Takinoue - Interface Focus, 2023 - royalsocietypublishing.org
Living systems are molecular assemblies whose dynamics are maintained by non-
equilibrium chemical reactions. To date, artificial cells have been studied from such physical …

Sequence-dependent fusion dynamics and physical properties of DNA droplets

Y Sato, M Takinoue - Nanoscale Advances, 2023 - pubs.rsc.org
Liquid–liquid phase separation (LLPS) of biopolymer molecules generates liquid-like
droplets. Physical properties such as viscosity and surface tension play important roles in …

Temporally controlled multistep division of DNA droplets for dynamic artificial cells

T Maruyama, J Gong, M Takinoue - Nature Communications, 2024 - nature.com
Synthetic droplets mimicking bio-soft matter droplets formed via liquid-liquid phase
separation (LLPS) in living cells have recently been employed in nanobiotechnology for …