STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich - Cytokine & growth factor …, 2016 - Elsevier
The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution
U Bharadwaj, MM Kasembeli, P Robinson… - Pharmacological …, 2020 - Elsevier
Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
Emergency granulopoiesis
MG Manz, S Boettcher - Nature Reviews Immunology, 2014 - nature.com
Neutrophils are a key cell type of the innate immune system. They are short-lived and need
to be continuously generated in steady-state conditions from haematopoietic stem and …
to be continuously generated in steady-state conditions from haematopoietic stem and …
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune
responses according to peripheral cues. After four decades of research, we now know that …
responses according to peripheral cues. After four decades of research, we now know that …
Development of monocytes, macrophages, and dendritic cells
Monocytes and macrophages are critical effectors and regulators of inflammation and the
innate immune response, the immediate arm of the immune system. Dendritic cells initiate …
innate immune response, the immediate arm of the immune system. Dendritic cells initiate …
Re (de) fining the dendritic cell lineage
Dendritic cells (DCs) are essential mediators of innate and adaptive immune responses.
Study of these critical cells has been complicated by their similarity to other hematopoietic …
Study of these critical cells has been complicated by their similarity to other hematopoietic …
Origin of the lamina propria dendritic cell network
Summary CX 3 CR1+ and CD103+ dendritic cells (DCs) in intestinal lamina propria play a
key role in mucosal immunity. However, the origin and the developmental pathways that …
key role in mucosal immunity. However, the origin and the developmental pathways that …
[HTML][HTML] Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues
Our understanding of conventional dendritic cell (cDC) development and the functional
specializations of distinct subsets in the peripheral tissues has increased greatly in recent …
specializations of distinct subsets in the peripheral tissues has increased greatly in recent …
Demand-adapted regulation of early hematopoiesis in infection and inflammation
H Takizawa, S Boettcher… - Blood, The Journal of the …, 2012 - ashpublications.org
During systemic infection and inflammation, immune effector cells are in high demand and
are rapidly consumed at sites of need. Although adaptive immune cells have high …
are rapidly consumed at sites of need. Although adaptive immune cells have high …
Steady-state and inflammatory dendritic-cell development
K Shortman, SH Naik - Nature Reviews Immunology, 2007 - nature.com
The developmental pathways that lead to the production of antigen-presenting dendritic
cells (DCs) are beginning to be understood. These are the last of the pathways of …
cells (DCs) are beginning to be understood. These are the last of the pathways of …