In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …

Beyond their role in hemostasis and thrombosis, platelets are increasingly recognized as
key regulators of the inflammatory response under sterile and infectious conditions. Both …

Increasing evidence suggests that platelets play a predominant role in colon and breast
cancer metastasis, but the underlying molecular mechanisms remain elusive. Glycoprotein …

Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on
megakaryocytes and platelets and is currently recognized as a receptor for not only collagen …

Platelets are the main players in thrombosis and hemostasis; however they also play
important roles during inflammation and infection. Through their surface receptors, platelets …

Breakdown of vascular barriers is a major complication of inflammatory diseases. Anucleate
platelets form blood-clots during thrombosis, but also play a crucial role in inflammation …

It has previously been shown in several animal experiments that platelet GPVI (glycoprotein
VI) contributes to thrombosis, particularly in ischemic stroke. Moreover, GPVI levels are …

Besides mediating hemostatic functions, platelets are increasingly recognized as important
players of inflammation. Data from experiments in mice and men revealed various …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with
high morbidity and mortality. Excessive neutrophil infiltration into the pulmonary airspace is …