Abstract Background The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese
medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the …

DExD/H-box helicases are crucial regulators of RNA metabolism and antiviral innate
immune responses; however, their role in bacteria-induced inflammation remains unclear …

Toll-like receptor-4 (TLR4) and sodium-glucose co-transporter 2 (SGLT2) signaling is
involved in the pathogenesis of diabetes-associated kidney diseases. The purpose of this …

Abstract Aim Targeting Toll-like receptor 4 (TLR4) and Angiotensin II type 1 receptor (AT1R)
could provide renoprotection during acute kidney injury (AKI) mainly by regulating …

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant neoplasm characterized by
a poor prognosis and limited therapeutic strategy. The PDAC tumor microenvironment …

Background Drug-induced acute kidney damage (DI-AKI) is a clinical phenomenon of rapid
loss of kidney function over a brief period of time as a consequence of the using of …

Background Macrophages are the main inflammatory cells involved in kidney injury and play
a significant role in the development of acute kidney injury (AKI) and progression of chronic …

Acute kidney injury (AKI) is a global health concern with high incidence and mortality, where
diabetes further worsens the condition. The available treatment options are not uniformly …

Objective Idiopathic nephrotic syndrome (INS) is the most common glomerular disease in
children. Toll-like receptors (TLRs) have been reported to be associated with response to …

器官获取与移植不可避免面对缺血再灌注损伤, 引起细胞内环境改变, 炎症反应, 活性氧聚集等,
影响移植物功能延迟恢复及远期移植器官结局. 尽管现阶段有较多研究改善缺血再灌注损伤 …