Cholesterol is an essential component of cell membranes and the precursor for the
synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially …

Covering: up to December 2018 The polycyclic ABCD (E) framework of triterpenoids can
miss a single endocyclic C–C bond as a result of a modification of the cyclization cascade …

The oxidosqualene cyclase (OSC) catalyzed cyclization of the linear substrate (3S)‐2, 3‐
oxidosqualene to form diverse pentacyclic triterpenoid (PT) skeletons is one of the most …

Pentacyclic triterpenes (PCT s) represent a major class of bioactive metabolites in banaba
(Lagerstroemia speciosa) leaves; however, biosynthetic enzymes and their involvement in …

Highlights•Understanding promiscuity in terpene synthases using multi-scale simulations.•
Promiscuity is a result of the inherent reactivity of carbocations.•Chemical control by active …

The remarkable cyclization mechanism of the formation of the 6‐6‐6‐5 tetracyclic lanosterol
(a key triterpenoid intermediate in the biosynthesis of cholesterol) from the acyclic 2, 3 …

Catalytic promiscuity, as a modern and imperfect understanding concept in enzyme catalysis
community, is prevailing in plant-derived sesquiterpene cyclases (FPPC) and highly related …

Terpenoids are a large structurally diverse group of natural products with an array of
functions in their hosts. The large amount of genomic information from recent sequencing …

SUMMARY Triterpenes (30‐carbon isoprene compounds) represent a large and highly
diverse class of natural products that play various physiological functions in plants. The …

The remarkable biochemical conversion of acyclic 2, 3-oxidosqualene to tetracyclic
lanosterol (the common precursor to cholesterol and its relatives) with seven stereocenters …