Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Signaling through the cyclic adenosine monophosphate–dependent protein kinase [protein
kinase A (PKA)] is an important and widely studied area of signal transduction research. This …

Local signaling domains and numerous interacting molecular pathways and substrates
contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS) …

Phosphodiesterases (PDEs) are the principal superfamily of enzymes responsible for
degrading the secondary messengers 3′, 5′-cyclic nucleotides cAMP and cGMP. Their …

Background New approaches are needed for large-scale predictive modeling of cellular
signaling networks. While mass action and enzyme kinetic approaches require extensive …

Correspondence to Jeffrey J. Saucerman: jsaucerman@ virginia. edu Abbreviations used in
this paper: AC, adenylyl cyclase; AKAP, A kinase–anchoring protein; MRP, multidrug …

Sudden cardiac death (SCD) is an unexpected death due to cardiac causes that occurs in a
short time period (generally within 1 h of symptom onset) in a person with known or …

β-Adrenergic receptors (βAR) play an important role in vasodilation, but the mechanisms
whereby adrenergic pathways regulate the endothelial isoform of nitric-oxide synthase …

BACKGROUND & AIMS: Significance of diastolic dysfunction in cirrhotic cardiomyopathy
has been brought to the forefront with several reports of unexpected heart failure following …

Obesity has been shown to impair myocardial performance. Some factors have been
suggested as responsible for possible cardiac abnormalities in models of obesity, among …