Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In
this study, we establish that aging of the immune system, regardless of the age of the stroma …

Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations,
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …

Abstract Analysis of the human hematopoietic progenitor compartment is being transformed
by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by …

While myelodysplastic syndromes with del (5q)(del (5q) MDS) comprises a well-defined
hematological subgroup, the molecular basis underlying its origin remains unknown. Using …

Sequencing of bulk tumor populations has improved genetic classification and risk
assessment of B-ALL, but does not directly examine intratumor heterogeneity or infer …

Background Hematopoiesis within the bone marrow (BM) is a complex and tightly regulated
process predominantly influenced by immune factors. Aging, diabetes, and obesity are …

Multiple myeloma (MM) is a heterogeneous and incurable tumor characterized by the
malignant proliferation of plasma cells. It is necessary to clarify the heterogeneity of MM and …

Background Myelodysplastic syndrome (MDS) is a complicated hematopoietic malignancy
characterized by bone marrow (BM) dysplasia with symptoms like anemia, neutropenia, or …

Chronic low-grade inflammation observed in older adults, termed inflammaging, is a
common feature underlying a multitude of aging-associated maladies including a decline in …

We describe MCProj—an algorithm for analyzing query scRNA-seq data by projections over
reference single-cell atlases. We represent the reference as a manifold of annotated …