In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

Ductal carcinoma in situ (DCIS) is an intraductal neoplastic proliferation of epithelial cells
that is separated from the breast stroma by an intact layer of basement membrane and …

Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to
subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been …

Breast cancer is the most common cancer in women and a leading cause of cancer-related
deaths for women worldwide. Various cell models have been developed to study breast …

Animal cell movement is effected through a combination of protrusive and contractile events.
Non-muscle cells contain stress fibres–bundles of actomyosin that are the major mediators …

Epithelial organs are built through the movement of groups of interconnected cells. We
observed cells in elongating mammary ducts reorganize into a multilayered epithelium …

The Hippo signaling pathway is a highly conserved potent regulator of cell growth, division,
and apoptosis. Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a …

Prostate epithelial cells from both normal and cancer tissues, grown in three-dimensional
(3D) culture as spheroids, represent promising in vitro models for the study of normal and …

Myofibroblasts produce and modify the extracellular matrix (ECM), secrete angiogenic and
pro‐inflammatory factors, and stimulate epithelial cell proliferation and invasion …

Numerous studies have demonstrated that the tumor microenvironment not only responds to
and supports carcinogenesis, but also actively contributes to tumor initiation, progression …