Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications

MT Silva, A Do Vale, NMN dos Santos - Apoptosis, 2008 - Springer
In metazoans apoptosis is a major physiological process of cell elimination during
development and in tissue homeostasis and can be involved in pathological situations. In …

Multiparametric flow cytometric analysis of biochemical and functional events associated with apoptosis and oncosis using the 7-aminoactinomycin D assay

H Lecoeur, LM de Oliveira-Pinto… - Journal of immunological …, 2002 - Elsevier
Apoptosis and primary necrosis are the two modes of cell death induced by a lethal injury.
The majority of structural and biochemical events occurring during cell death can be …

Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy

SJ Kim, JS Kim, ES Park, JS Lee, Q Lin, RR Langley… - Neoplasia, 2011 - Elsevier
In the United States, more than 40% of cancer patients develop brain metastasis. The
median survival for untreated patients is 1 to 2 months, which may be extended to 6 months …

Effect of N-acetyl-L-cysteine on ROS production and cell death caused by HEMA in human primary gingival fibroblasts

G Spagnuolo, V D'Antò, C Cosentino, G Schmalz… - Biomaterials, 2006 - Elsevier
Previous investigations have shown that 2-hydroxyethyl methacrylate (HEMA) causes
reactive oxygen species (ROS) production, which in turn affects cell survival and cell death …

Effects of phenol on barrier function of a human intestinal epithelial cell line correlate with altered tight junction protein localization

IC McCall, A Betanzos, DA Weber, P Nava… - Toxicology and applied …, 2009 - Elsevier
Phenol contamination of soil and water has raised concerns among people living near
phenol-producing factories and hazardous waste sites containing the chemical. Phenol …

Interactions between Brucella melitensis and Human Phagocytes: Bacterial Surface O-Polysaccharide Inhibits Phagocytosis, Bacterial Killing, and Subsequent Host …

CM Fernandez-Prada, EB Zelazowska… - Infection and …, 2003 - Am Soc Microbiol
Brucellae are gram-negative intracellular pathogens that survive and multiply within host
phagocytic cells. Smooth organisms present O-polysaccharides (OPS) on their surface. The …

Quantitative analysis of macrophage apoptosis vs. necrosis induced by cobalt and chromium ions in vitro

I Catelas, A Petit, H Vali, C Fragiskatos, R Meilleur… - Biomaterials, 2005 - Elsevier
The potential toxicity of metal ions in tissues surrounding metal–metal hip replacements is a
cause for concern. Previous studies conducted in our laboratory demonstrated that Co2+ …

NAD+‐glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci

AL Bricker, C Cywes, CD Ashbaugh… - Molecular …, 2002 - Wiley Online Library
Group A streptococci (GAS) produce several secreted products that are thought to enhance
pathogenicity by facilitating spread of the organisms through host tissues. Two such …

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

V Papa, PL Tazzari, F Chiarini, A Cappellini, F Ricci… - Leukemia, 2008 - nature.com
The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase
(PI3K), is known to play an important role in antiapoptotic signaling and has been implicated …

Inhibition of apoptosis and caspase‐3 in vascular smooth muscle cells by plasminogen activator inhibitor type‐1

Y Chen, RJ Kelm Jr, RC Budd, BE Sobel… - Journal of cellular …, 2004 - Wiley Online Library
Increased expression of plasminogen activator inhibitor type 1 (PAI‐1) is associated with
decreased apoptosis of neoplastic cells. We sought to determine whether PAI‐1 alters …