Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram
metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell …

Immune-mediated inflammatory diseases (IMIDs) encompass a wide range of seemingly
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …

Since human Nucleoside Transporters (hNTs) were identified by their activity as transport
systems, extensive work has been done to fully characterize them at the molecular and …

Humans do not produce uricase, an enzyme responsible for degrading uric acid. However,
some bacteria residing in the gut can degrade one-third of the dietary and endogenous uric …

The influence of pharmacogenetics in tacrolimus pharmacokinetics and pharmacodynamics
needs further investigation, considering its potential in assisting clinicians to predict the …

Extracellular adenosine concentrations are regulated by a panel of membrane transporters
which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two …

Nucleosides play central roles in all facets of life, from metabolism to cellular signaling.
Because of their physiochemical properties, nucleosides are lipid bilayer impermeable and …

Simple Summary Despite the enormous advance in biomarker discovery, many potential
biomarkers of drug activity are unable to satisfy the clinical need due to inadequate …

Adenosine is a purine nucleoside, resulting from the degradation of adenosine triphosphate
(ATP). Under adverse conditions, including hypoxia, ischemia, inflammation, or cancer, the …

Introduction Nucleoside analogs are an important class of antiviral agents. Due to the high
hydrophilicity and limited membrane permeability of antiviral nucleoside/nucleotide analogs …