Carotenoid metabolism at the intestinal barrier

J von Lintig, J Moon, J Lee, S Ramkumar - Biochimica et Biophysica Acta …, 2020 - Elsevier
Carotenoids exert a rich variety of physiological functions in mammals and are beneficial for
human health. These lipids are acquired from the diet and metabolized to apocarotenoids …

Generating and using transcriptomically based retinal cell atlases

K Shekhar, JR Sanes - Annual Review of Vision Science, 2021 - annualreviews.org
It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …

[HTML][HTML] SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

W Sungnak, N Huang, C Bécavin, M Berg, R Queen… - Nature medicine, 2020 - nature.com
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-
associated genes in single-cell RNA-sequencing data from multiple tissues from healthy …

[HTML][HTML] Cell types of the human retina and its organoids at single-cell resolution

CS Cowan, M Renner, M De Gennaro, B Gross-Scherf… - Cell, 2020 - cell.com
Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

[HTML][HTML] Single-cell transcriptomic comparison of human fetal retina, hPSC-derived retinal organoids, and long-term retinal cultures

A Sridhar, A Hoshino, CR Finkbeiner, A Chitsazan… - Cell reports, 2020 - cell.com
To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …

A single‐cell transcriptome atlas of the adult human retina

SW Lukowski, CY Lo, AA Sharov, Q Nguyen… - The EMBO …, 2019 - embopress.org
The retina is a specialized neural tissue that senses light and initiates image processing.
Although the functional organization of specific retina cells has been well studied, the …

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

AP Voigt, K Mulfaul, NK Mullin… - Proceedings of the …, 2019 - National Acad Sciences
The human retinal pigment epithelium (RPE) and choroid are complex tissues that provide
crucial support to the retina. Disease affecting either of these supportive tissues can lead to …

Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

Y Lu, F Shiau, W Yi, S Lu, Q Wu, JD Pearson… - Developmental cell, 2020 - cell.com
The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …

Cell atlas of the human fovea and peripheral retina

W Yan, YR Peng, T van Zyl, A Regev, K Shekhar… - Scientific reports, 2020 - nature.com
Most irreversible blindness results from retinal disease. To advance our understanding of
the etiology of blinding diseases, we used single-cell RNA-sequencing (scRNA-seq) to …

[HTML][HTML] Integration of eQTL and a single-cell atlas in the human eye identifies causal genes for age-related macular degeneration

LD Orozco, HH Chen, C Cox, KJ Katschke, R Arceo… - Cell reports, 2020 - cell.com
Age-related macular degeneration (AMD) is a leading cause of vision loss. To better
understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we …