Technological developments in lncRNA biology
S Jathar, V Kumar, J Srivastava, V Tripathi - Long Non Coding RNA …, 2017 - Springer
It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …
RNA sequencing: advances, challenges and opportunities
F Ozsolak, PM Milos - Nature reviews genetics, 2011 - nature.com
In the few years since its initial application, massively parallel cDNA sequencing, or RNA-
seq, has allowed many advances in the characterization and quantification of …
seq, has allowed many advances in the characterization and quantification of …
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
Abstract N 6-methyladenosine (m6A) is the most abundant modified base in eukaryotic
mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches …
mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches …
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
Single-cell gene expression analyses hold promise for characterizing cellular heterogeneity,
but current methods compromise on either the coverage, the sensitivity or the throughput …
but current methods compromise on either the coverage, the sensitivity or the throughput …
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites
Summary N6-methyladenosine (m6A) is a common modification of mRNA with potential
roles in fine-tuning the RNA life cycle. Here, we identify a dense network of proteins …
roles in fine-tuning the RNA life cycle. Here, we identify a dense network of proteins …
Landscape and regulation of m6A and m6Am methylome across human and mouse tissues
Summary N 6-methyladenosine (m 6 A), the most abundant internal mRNA modification, and
N 6, 2′-O-dimethyladenosine (m 6 Am), found at the first-transcribed nucleotide, are two …
N 6, 2′-O-dimethyladenosine (m 6 Am), found at the first-transcribed nucleotide, are two …
Update of the FANTOM web resource: expansion to provide additional transcriptome atlases
M Lizio, I Abugessaisa, S Noguchi, A Kondo… - Nucleic acids …, 2019 - academic.oup.com
The FANTOM web resource (http://fantom. gsc. riken. jp/) was developed to provide easy
access to the data produced by the FANTOM project. It contains the most complete and …
access to the data produced by the FANTOM project. It contains the most complete and …
Computational methods for transcriptome annotation and quantification using RNA-seq
High-throughput RNA sequencing (RNA-seq) promises a comprehensive picture of the
transcriptome, allowing for the complete annotation and quantification of all genes and their …
transcriptome, allowing for the complete annotation and quantification of all genes and their …
Metazoan promoters: emerging characteristics and insights into transcriptional regulation
Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …
elements, sequence motifs, the choice of transcription start sites and other features. Several …
[HTML][HTML] Discovery and functional analysis of lncRNAs: Methodologies to investigate an uncharacterized transcriptome
K Kashi, L Henderson, A Bonetti, P Carninci - Biochimica et Biophysica …, 2016 - Elsevier
It is known that more than 70% of mammalian genomes are transcribed, yet the vast majority
of transcripts do not code for proteins. Are these noncoding transcripts merely transcriptional …
of transcripts do not code for proteins. Are these noncoding transcripts merely transcriptional …