Muscle and neuronal nicotinic acetylcholine receptors: structure, function and pathogenicity
D Kalamida, K Poulas, V Avramopoulou… - The FEBS …, 2007 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …
Crystallizing membrane proteins for structure determination: use of lipidic mesophases
M Caffrey - Annual review of biophysics, 2009 - annualreviews.org
The principal route to determine the structure and the function and interactions of membrane
proteins is via macromolecular crystallography. For macromolecular crystallography to be …
proteins is via macromolecular crystallography. For macromolecular crystallography to be …
Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors
The crystal structure of the snake long α‐neurotoxin, α‐cobratoxin, bound to the pentameric
acetylcholine‐binding protein (AChBP) from Lymnaea stagnalis, was solved from good …
acetylcholine‐binding protein (AChBP) from Lymnaea stagnalis, was solved from good …
Room to move: crystallizing membrane proteins in swollen lipidic mesophases
The cubic phase or in meso crystallization method is responsible for almost 40 solved
integral membrane protein structures. Most of these are small and compact proteins. A …
integral membrane protein structures. Most of these are small and compact proteins. A …
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism
We present a three-dimensional model of the homopentameric α7 nicotinic acetylcholine
receptor (nAChR), that includes the extracellular and membrane domains, developed by …
receptor (nAChR), that includes the extracellular and membrane domains, developed by …
Gating of pentameric ligand-gated ion channels: structural insights and ambiguities
JB Corrie, JE Baenziger - Structure, 2013 - cell.com
Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic communication by
converting chemical signals into an electrical response. Recently solved agonist-bound and …
converting chemical signals into an electrical response. Recently solved agonist-bound and …
Insight in nAChR subtype selectivity from AChBP crystal structures
P Rucktooa, AB Smit, TK Sixma - Biochemical pharmacology, 2009 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) display a broad variety of subtypes, which in turn
present a complex subcellular and regional expression pattern in the brain, as well as a …
present a complex subcellular and regional expression pattern in the brain, as well as a …
Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes
The crystal structure of the β2-adrenergic receptor in complex with an agonist and its
cognate G protein has just recently been determined. It is now possible to explore in …
cognate G protein has just recently been determined. It is now possible to explore in …
Membrane protein crystallization in lipidic mesophases with tailored bilayers
LV Misquitta, Y Misquitta, V Cherezov, O Slattery… - Structure, 2004 - cell.com
Monoacylglycerols have been used as bilayered hosts for growing crystals of membrane
proteins. To date, the lipids used have had chains 16 and 18 carbon atoms long. We …
proteins. To date, the lipids used have had chains 16 and 18 carbon atoms long. We …
Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors
Nicotinic acetylcholine receptors (nAChR) are pentameric ligand-gated ion channels
composed of subunits that consist of an extracellular domain that carries the ligand-binding …
composed of subunits that consist of an extracellular domain that carries the ligand-binding …