Polycystic kidney diseases are inherited renal disorders due mainly to mutations in genes
that regulate the development and function of cells that line renal tubules. This review …

The AP-2 family of transcription factors consists of five different proteins in humans and mice:
AP-2α, AP-2β, AP-2γ, AP-2δ and AP-2ε. Frogs and fish have known orthologs of some but …

Kidney failure, the decrease of kidney function below a threshold necessary to support life, is
a major cause of morbidity and mortality. We performed a genome-wide association study …

The activated product of the myc oncogene deregulates both cell growth and death check
points and, in a permissive environment, rapidly accelerates the affected clone through the …

Much recent research on c-Myc has focused on how it drives apoptosis. c-Myc is widely
known as a crucial regulator of cell proliferation in normal and neoplastic cells, but until …

AP-2 transcription factors represent a family of three closely related and evolutionarily
conserved sequence-specific DNA-binding proteins, AP-2α,-β and-γ. Subsequent studies …

Char syndrome is an autosomal dominant trait characterized by patent ductus arteriosus,
facial dysmorphism and hand anomalies. Using a positional candidacy strategy, we mapped …

Development of an organ is directed by cell and tissue interactions and these also occur
during the formation of functional kidney. During vertebrate development inductive signalling …

The members of the AP-2 family of transcription factors play important roles during
mammalian development and morphogenesis. AP-2γ (Tcfap2c–Mouse Genome Informatics) …

MafB is a member of the large Maf family of transcription factors that share similar basic
region/leucine zipper DNA binding motifs and N-terminal activation domains. Although it is …