[PDF][PDF] Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside
In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …
The extracellular matrix–the under‐recognized element in lung disease?
The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM)
contains the main building blocks of both components. The ECM provides physical support …
contains the main building blocks of both components. The ECM provides physical support …
Acute exacerbations of idiopathic pulmonary fibrosis
HR Collard, BB Moore, KR Flaherty… - American journal of …, 2007 - atsjournals.org
The natural history of idiopathic pulmonary fibrosis (IPF) has been characterized as a
steady, predictable decline in lung function over time. Recent evidence suggests that some …
steady, predictable decline in lung function over time. Recent evidence suggests that some …
Fibrocytes: emerging effector cells in chronic inflammation
Fibrocytes are mesenchymal cells that arise from monocyte precursors. They are present in
injured organs and have both the inflammatory features of macrophages and the tissue …
injured organs and have both the inflammatory features of macrophages and the tissue …
Fibroblast-to-myofibroblast transition in bronchial asthma
Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling
plays a significant role. This phenomenon is related to enhanced proliferation of airway …
plays a significant role. This phenomenon is related to enhanced proliferation of airway …
Epithelium dysfunction in asthma
ST Holgate - Journal of Allergy and Clinical Immunology, 2007 - Elsevier
Although asthma is an inflammatory disorder of the conducting airways involving TH2-type T
cells, there is increasing evidence for an important role played by the epithelium in …
cells, there is increasing evidence for an important role played by the epithelium in …
Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis
Rationale: The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major
challenge due to lack of effective drug therapy or accurate indicators for disease …
challenge due to lack of effective drug therapy or accurate indicators for disease …
Induction of epithelial–mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-β1
Rationale: Airway remodeling in asthma is associated with the accumulation of fibroblasts,
the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The …
the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The …
[HTML][HTML] The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses
A Bellini, S Mattoli - Laboratory investigation, 2007 - Elsevier
Human fibrocytes are mesenchymal progenitors that exhibit mixed morphological and
molecular characteristics of hematopoietic stem cells, monocytes and fibroblasts. They likely …
molecular characteristics of hematopoietic stem cells, monocytes and fibroblasts. They likely …
Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype
M Pain, O Bermudez, P Lacoste… - European …, 2014 - Eur Respiratory Soc
Airway remodelling is a critical feature of chronic bronchial diseases, characterised by
aberrant repair of the epithelium and accumulation of fibroblasts, which contribute to …
aberrant repair of the epithelium and accumulation of fibroblasts, which contribute to …