Towards a deeper understanding of the vaginal microbiota
The human vaginal microbiota is a critical determinant of vaginal health. These communities
live in close association with the vaginal epithelium and rely on host tissues for resources …
live in close association with the vaginal epithelium and rely on host tissues for resources …
The complex link between the female genital microbiota, genital infections, and inflammation
The female genital tract microbiota is part of a complex ecosystem influenced by several
physiological, genetic, and behavioral factors. It is uniquely linked to a woman's mucosal …
physiological, genetic, and behavioral factors. It is uniquely linked to a woman's mucosal …
Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
Background Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at
reduced risk of acquiring sexually transmitted infections including HIV, but the biological …
reduced risk of acquiring sexually transmitted infections including HIV, but the biological …
Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip
G Mahajan, E Doherty, T To, A Sutherland, J Grant… - Microbiome, 2022 - Springer
Background A dominance of non-iners Lactobacillus species in the vaginal microbiome is
optimal and strongly associated with gynecological and obstetric health, while the presence …
optimal and strongly associated with gynecological and obstetric health, while the presence …
Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation
SM Bloom, NA Mafunda, BM Woolston… - Nature …, 2022 - nature.com
Vaginal microbiota composition affects many facets of reproductive health. Lactobacillus
iners-dominated microbial communities are associated with poorer outcomes, including …
iners-dominated microbial communities are associated with poorer outcomes, including …
Lactic acid enhances vaginal epithelial barrier integrity and ameliorates inflammatory effects of dysbiotic short chain fatty acids and HIV-1
The vaginal microenvironment is key in mediating susceptibility to sexually transmitted
infections. A polymicrobial environment with reduced Lactobacilllus spp. is characteristic of …
infections. A polymicrobial environment with reduced Lactobacilllus spp. is characteristic of …
Vaginal microbiome composition in early pregnancy and risk of spontaneous preterm and early term birth among African American women
Objective To evaluate the association between the early pregnancy vaginal microbiome and
spontaneous preterm birth (sPTB) and early term birth (sETB) among African American …
spontaneous preterm birth (sPTB) and early term birth (sETB) among African American …
Epidemiologic evidence on the role of Lactobacillus iners in sexually transmitted infections and bacterial vaginosis: a series of systematic reviews and meta-analyses
KA Carter, MD Fischer, MI Petrova… - Sexually transmitted …, 2023 - journals.lww.com
Although Lactobacillus crispatus–dominated vaginal microbiotas are thought to protect
against bacterial vaginosis (BV) and sexually transmitted infections, the role of Lactobacillus …
against bacterial vaginosis (BV) and sexually transmitted infections, the role of Lactobacillus …
Impact of estrogen and progesterone on immune cells and host–pathogen interactions in the lower female reproductive tract
MK Collins, CR McCutcheon… - The Journal of …, 2022 - journals.aai.org
Microbial infections are a threat to women's reproductive health. Although reproductive
cycles and pregnancy are controlled by sex hormones, the impact of hormones on host …
cycles and pregnancy are controlled by sex hormones, the impact of hormones on host …
Gardnerella Revisited: Species Heterogeneity, Virulence Factors, Mucosal Immune Responses, and Contributions to Bacterial Vaginosis
E Shvartsman, JE Hill, P Sandstrom… - Infection and …, 2023 - Am Soc Microbiol
Gardnerella species are associated with bacterial vaginosis (BV) and have been
investigated as etiological agents of the condition. Nonetheless, the isolation of this taxon …
investigated as etiological agents of the condition. Nonetheless, the isolation of this taxon …